ArticleAmerican journal of human genetics1998
Mapping of complex traits by single-nucleotide polymorphisms.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- A gene frequency model for QTL mapping using Bayesian inference.Genetics, selection, evolution : GSE · 2010Article
- Article
- Association testing in a linked region using large pedigrees.American journal of human genetics · 2005Article
- The future of genetic testing for drug response.Dialogues in clinical neuroscience · 2004Article
- Fine mapping of complex trait genes combining pedigree and linkage disequilibrium information: a Bayesian unified framework.Genetics · 2003Article
- Maximizing the value of medicines by including pharmacogenetic research in drug development and surveillance.British journal of clinical pharmacology · 2002Review
- Homogeneous assays for single-nucleotide polymorphism typing using AlphaScreen.Genome research · 2001Article
- Detection of mitochondrial single nucleotide polymorphisms using a primer elongation reaction on oligonucleotide microarrays.Nucleic acids research · 2001Article
- Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma.Respiratory research · 2001Review
- Expression-based genetic/physical maps of single-nucleotide polymorphisms identified by the cancer genome anatomy project.Genome research · 2000Article
- Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.American journal of human genetics · 2000Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Molecular geneticists are developing the third-generation human genome map with single-nucleotide polymorphisms (SNPs), which can be assayed via chip-based microarrays. One use of these SNP markers is the ability to locate loci that may be responsible for complex traits, via linkage/linkage-disequilibrium analysis. In this communication, we describe a semiparametric method for combined linkage/linkage-disequilibrium analysis using SNP markers. Asymptotic results are obtained for the estimated parameters, and the finite-sample properties are evaluated via a simulation study. We also applied this technique to a simulated genome-scan experiment for mapping a complex trait with two major genes. This experiment shows that separate linkage and linkage-disequilibrium analyses correctly detected the signals of both major genes; but the rates of false-positive signals seem high. When linkage and linkage-disequilibrium signals were combined, the analysis yielded much stronger and clearer signals for the presence of two major genes than did two separate analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.