ArticleAmerican journal of human genetics1998
Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
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Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.Human molecular genetics · 2011Pooled it
- Global and Local Ancestry and its Importance: A Review.Current genomics · 2024Review
- Impact of cross-ancestry genetic architecture on GWASs in admixed populations.American journal of human genetics · 2023Article
- Impact of cross-ancestry genetic architecture on GWAS in admixed populations.bioRxiv : the preprint server for biology · 2023Article
- Individualized Medicine in Africa: Bringing the Practice Into the Realms of Population Heterogeneity.Frontiers in genetics · 2022Article
- What the Jackson Heart Study Has Taught Us About Diabetes and Cardiovascular Disease in the African American Community: a 20-year Appreciation.Current diabetes reports · 2021Review
- Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases.International journal of molecular sciences · 2021Review
- An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations.Frontiers in genetics · 2021Review
- Genome-wide Significance Thresholds for Admixture Mapping Studies.American journal of human genetics · 2019Article
- Population Stratification in Genetic Association Studies.Current protocols in human genetics · 2017Review
- Genomic selection models double the accuracy of predicted breeding values for bacterial cold water disease resistance compared to a traditional pedigree-based model in rainbow trout aquaculture.Genetics, selection, evolution : GSE · 2017Article
- Article
- Genetic ancestry is associated with measures of subclinical atherosclerosis in African Americans: the Jackson Heart Study.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Mapping asthma-associated variants in admixed populations.Frontiers in genetics · 2015Review
- Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping.European journal of human genetics : EJHG · 2014Article
- Use of admixture and association for detection of quantitative trait loci in the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Ethnic Samples (T2D-GENES) study.BMC proceedings · 2014Article
- Admixture mapping of quantitative traits in Populus hybrid zones: power and limitations.Heredity · 2013Article
- Generalized admixture mapping for complex traits.G3 (Bethesda, Md.) · 2013Article
- Review
- Extending admixture mapping to nuclear pedigrees: application to sarcoidosis.Genetic epidemiology · 2013Article
47 more citing papers are in PubMed but not listed here.
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1 author.
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Abstract
Genes that underlie ethnic differences in disease risk can be mapped in affected individuals of mixed descent if the ancestry of the alleles at each marker locus can be assigned to one of the two founding populations. Linkage can be detected by testing for association of the disease with the ancestry of alleles at the marker locus, by conditioning on the admixture (defined as the proportion of genes that have ancestry from the high-risk population) of both parents. With regard to exploiting the effects of admixture, this test is more flexible and powerful than the transmission-disequilibrium test. Under the assumption of a multiplicative model, the statistical power for a given sample size depends only on parental admixture and the risk ratio r between populations that is generated by the locus. The most informative families are those in which mean parental admixture is .2-.7 and in which admixture is similar in both parents. The number of markers required for a genome search depends on the number of generations since admixture and on the information content for ancestry (f) of the markers, defined as a function of allele frequencies in the two founding populations. Simulations using a hidden Markov model suggest that, when admixture has occurred 2-10 generations earlier, a multipoint analysis using 2,000 biallelic markers, with f values of 30%, can extract 70%-90% of the ancestry information for each locus. Sets of such markers could be selected from libraries of single-nucleotide polymorphisms, when these become available.
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