ArticleAmerican journal of human genetics1998
Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 131 citations in OpenAlex.
- Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspectsTurkish journal of medical sciences · 2021Review
- Article
- A cautionary note on the impact of protocol changes for genome-wide association SNP × SNP interaction studies: an example on ankylosing spondylitis.Human genetics · 2015Article
- Fine mapping of eight psoriasis susceptibility loci.European journal of human genetics : EJHG · 2015Article
- Genetics of susceptibility and treatment response in psoriatic arthritis.Nature reviews. Rheumatology · 2011Review
- A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.Nature genetics · 2010Article
- Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1.Tissue antigens · 2010Article
- Current concepts in the pathogenesis of psoriasis.Indian journal of dermatology · 2009Article
- Genetics of psoriasis and psoriatic arthritis: update and future direction.The Journal of rheumatology · 2008Review
- [Molecular genetic basis of predisposition to psoriasis].Genetika · 2008Review
- Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population.PLoS genetics · 2008Article
- Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype.Genes and immunity · 2007Article
- Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.American journal of human genetics · 2006Article
- Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.Human genetics · 2005Article
- Genetic factors in psoriatic arthritis.Current rheumatology reports · 2005Review
- Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).American journal of human genetics · 2005Article
- Immunopathogenic mechanisms in psoriasis.Clinical and experimental immunology · 2004Review
- Reduced IFN-gamma responses associated with HLA-DR15 presentation of streptococcal cell wall proteins to dermal Th-1 cells in psoriasis.Journal of clinical immunology · 2003Article
- A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting.American journal of human genetics · 2003Article
- Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis.American journal of human genetics · 2002Article
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10 authors at 2 institutions in 2 countries.
Funding
Abstract
Although psoriasis is strongly associated with certain human leukocyte antigens (HLAs), evidence for linkage to HLA markers has been limited. The objectives of this study were (1) to provide more definitive evidence for linkage of psoriasis to HLA markers in multiplex families; (2) to compare the major HLA risk alleles in these families with those determined by previous case-control studies; and (3) to localize the gene more precisely. By applying the transmission/disequilibrium test (TDT) and parametric linkage analysis, we found evidence for linkage of psoriasis to HLA-C, -B, -DR, and -DQ, with HLA-B and -C yielding the most-significant results. Linkage was detectable by parametric methods only when marker-trait disequilibrium was considered. Case-control association tests and the TDT identified alleles belonging to the EH57.1 ancestral haplotype as the major risk alleles in our sample. Among individuals carrying recombinant ancestral haplotypes involving EH57. 1, the class I markers were retained selectively among affecteds four times more often than among unaffecteds; among the few affected individuals carrying only the class II alleles from the ancestral haplotype, all but one also carried Cw6. These data show that familial and "sporadic" psoriasis share the same risk alleles. They also illustrate that substantial parametric linkage information can be extracted by accounting for linkage disequilibrium. Finally, they strongly suggest that a major susceptibility gene resides near HLA-C.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.