ArticleMolecular and cellular biology1998
The C-terminal domain of Sin1 interacts with the SWI-SNF complex in yeast.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- GBAF, a small BAF sub-complex with big implications: a systematic review.Epigenetics & chromatin · 2020Pooled it
- A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs.The Journal of biological chemistry · 2019Article
- Multiple transcription factors contribute to inter-chromosomal interaction in yeast.BMC systems biology · 2018Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- Inactivation of chromatin remodeling factors sensitizes cells to selective cytotoxic stress.Biologics : targets & therapy · 2014Article
- Casein kinase 2 associates with the yeast chromatin reassembly factor Spt2/Sin1 to regulate its function in the repression of spurious transcription.Molecular and cellular biology · 2013Article
- A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.G3 (Bethesda, Md.) · 2012Article
- Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.PLoS genetics · 2008Article
- A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region.Molecular and cellular biology · 2006Article
- Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.Molecular and cellular biology · 2002Article
- Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation.Molecular and cellular biology · 2002Article
- Review
- Artificially recruited TATA-binding protein fails to remodel chromatin and does not activate three promoters that require chromatin remodeling.Molecular and cellular biology · 2000Article
- Cell cycle-regulated histone acetylation required for expression of the yeast HO gene.Genes & development · 1999Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the yeast Saccharomyces cerevisiae, the SWI-SNF complex has been proposed to antagonize the repressive effects of chromatin by disrupting nucleosomes. The SIN genes were identified as suppressors of defects in the SWI-SNF complex, and the SIN1 gene encodes an HMG1-like protein that has been proposed to be a component of chromatin. Specific mutations (sin mutations) in both histone H3 and H4 genes produce the same phenotypic effects as do mutations in the SIN1 gene. In this study, we demonstrate that Sin1 and the H3 and H4 histones interact genetically and that the C terminus of Sin1 physically associates with components of the SWI-SNF complex. In addition, we demonstrate that this interaction is blocked in the full-length Sin1 protein by the N-terminal half of the protein. Based on these and additional results, we propose that Sin1 acts as a regulatable bridge between the SWI-SNF complex and the nucleosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.