ArticleMolecular and cellular biology1998
Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- The bidirectional interplay between RNA processing and mechanotransduction.Cell reports · 2025Review
- FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.Scientific reports · 2025Article
- Circular RNA Gtdc1 Protects Against Offspring Osteoarthritis Induced by Prenatal Prednisone Exposure by Regulating SRSF1-Fn1 Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin.Breast cancer research : BCR · 2023Article
- Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction.iScience · 2023Article
- Native functions of short tandem repeats.eLife · 2023Article
- Identification of splice regulators of fibronectin-EIIIA and EIIIB by direct measurement of exon usage in a flow-cytometry based CRISPR screen.Scientific reports · 2021Article
- Article
- Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors.Molecular cell · 2015Article
- RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins.Molecular cell · 2014Article
- Rbfox2 controls autoregulation in RNA-binding protein networks.Genes & development · 2014Article
- Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges.Nature structural & molecular biology · 2013Article
- Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation.RNA (New York, N.Y.) · 2013Article
- Mutually exclusive splicing regulates the Nav 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands.Nucleic acids research · 2012Article
- Splicosomal and serine and arginine-rich splicing factors as targets for TGF-β.Fibrogenesis & tissue repair · 2012Article
- The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.Genes & development · 2012Article
- Variants affecting exon skipping contribute to complex traits.PLoS genetics · 2012Article
- RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.Molecular and cellular biology · 2012Article
- Nonsense mutation-associated Becker muscular dystrophy: interplay between exon definition and splicing regulatory elements within the DMD gene.Human mutation · 2011Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The fibronectin EIIIB exon is alternatively spliced in a cell-type-specific manner, and TGCATG repeats in the intron downstream of EIIIB have been implicated in this regulation. Analysis of the intron sequence from several vertebrates shows that the pattern of repeats in the 3' half of the intron is evolutionarily conserved. Point mutations in certain highly conserved repeats greatly reduce EIIIB inclusion, suggesting that a multicomponent complex may recognize the repeats. Expression of the SR protein SRp40, SRp20, or ASF/SF2 stimulates EIIIB inclusion. Studies of the interplay between mutations in the repeats and SRp40-stimulated inclusion suggest that the repeats are recognized in many, if not all, cell types, and that EIIIB inclusion may be regulated by quantitative changes in multiple factors.
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