ArticleMolecular and cellular biology1998
Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking.Nature communications · 2016Article
- Ezrin is a Major Regulator of Membrane Tension in Epithelial Cells.Scientific reports · 2015Article
- PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.The Journal of cell biology · 2015Article
- Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway.Biochimica et biophysica acta · 2015Article
- INPP4B suppresses prostate cancer cell invasion.Cell communication and signaling : CCS · 2014Article
- Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia.Haematologica · 2014Article
- Myosin 1e is a component of the invadosome core that contributes to regulation of invadosome dynamics.Experimental cell research · 2014Article
- Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.Biochemical and biophysical research communications · 2013Article
- Src binds cortactin through an SH2 domain cystine-mediated linkage.Journal of cell science · 2012Article
- Article
- Myosin IIB deficiency in embryonic fibroblasts affects regulators and core members of the par polarity complex.Histochemistry and cell biology · 2011Article
- The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis.Molecular and cellular biology · 2011Article
- PTP1B: a double agent in metabolism and oncogenesis.Trends in biochemical sciences · 2010Review
- Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions.Molecular biology of the cell · 2007Article
- PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes.Biochimica et biophysica acta · 2006Article
- Actin cytoskeleton remodelling in the anterior pituitary folliculostellate cell line TtT/GF: participation of the actin-binding protein cortactin.Journal of molecular histology · 2005Article
- Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain.BMC genomics · 2005Article
- Cortactin signalling and dynamic actin networks.The Biochemical journal · 2004Review
- Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization.The Biochemical journal · 2003Article
- Aberrant HS1 molecule in a patient with systemic lupus erythematosus.Genes and immunity · 2003Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncogenic Ras mutants such as v-Ha-Ras cause a rapid rearrangement of actin cytoskeleton during malignant transformation of fibroblasts or epithelial cells. Both PI-3 kinase and Rac are required for Ras-induced malignant transformation and membrane ruffling. However, the signal transduction pathway(s) downstream of Rac that leads to membrane ruffling and other cytoskeletal change(s) as well as the exact biochemical nature of the cytoskeletal change remain unknown. Cortactin/EMS1 is the first identified molecule that is dissociated in a Rac-phosphatidylinositol 4,5-biphosphate (PIP2)-dependent manner from the actin-myosin II complex during Ras-induced malignant transformation; either the PIP2 binder HS1 or the Rac blocker SCH51344 restores the ability of EMS1 to bind the complex and suppresses the oncogenicity of Ras. Furthermore, while PIP2 inhibits the actin-EMS1 interaction, HS1 reverses the PIP2 effect. Thus, we propose that PIP2, an end-product of the oncogenic Ras/PI-3 kinase/Rac pathway, serves as a second messenger in the Ras/Rac-induced disruption of the actin cytoskeleton and discuss the anticancer drug potential of PIP2-binding molecules.
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