ArticleMolecular and cellular biology1998
Xenopus TFIIIA gene transcription is dependent on cis-element positioning and chromatin structure.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Alternative splicing of anciently exonized 5S rRNA regulates plant transcription factor TFIIIA.Genome research · 2009Article
- Candidate regulatory sequence elements for cell cycle-dependent transcription in Saccharomyces cerevisiae.Genome research · 1999Article
- The chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression.Journal of virology · 1999Article
- Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Xenopus TFIIIA gene is transcribed very efficiently in oocytes. In addition to a TATA element at -30, we show that from -425 to +7 the TFIIIA gene contains only two positive cis elements centered at -267 (element 1) and -230 (element 2). This arrangement of the cis elements in the TFIIIA gene is striking because these two elements are positioned very close to each other yet separated from the TATA element by approximately 190 nucleotides. We show that the 190-nucleotide spacing between the TATA element and the upstream cis elements (elements 1 and 2) is critical for efficient transcription of the gene in oocytes and that a nucleosome is positioned in this intervening region. This nucleosome may act positively on TFIIIA transcription in oocytes by placing transcription factors bound at elements 1 and 2 in a favorable position relative to the transcription complex at the TATA element.
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Registered trials
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