ArticleMolecular and cellular biology1998
Mutational analysis of an RNA recognition element that mediates localization of bicoid mRNA.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Organizing the oocyte: RNA localization meets phase separation.Current topics in developmental biology · 2020Article
- DistinctDevelopment (Cambridge, England) · 2018Article
- Translational co-regulation of a ligand and inhibitor by a conserved RNA element.Nucleic acids research · 2018Article
- A stem-loop structure directs oskar mRNA to microtubule minus ends.RNA (New York, N.Y.) · 2014Article
- Of social molecules: The interactive assembly of ASH1 mRNA-transport complexes in yeast.RNA biology · 2014Review
- mRNA on the move: the road to its biological destiny.The Journal of biological chemistry · 2013Review
- Molecular insights into intracellular RNA localization.International review of cell and molecular biology · 2013Review
- RNA-ID, a highly sensitive and robust method to identify cis-regulatory sequences using superfolder GFP and a fluorescence-based assay.RNA (New York, N.Y.) · 2012Article
- Principles and roles of mRNA localization in animal development.Development (Cambridge, England) · 2012Review
- Assembly of mRNA-protein complexes for directional mRNA transport in eukaryotes--an overview.Current protein & peptide science · 2012Review
- Identification of 3'UTR sequence elements and a teloplasm localization motif sufficient for the localization of Hro-twist mRNA to the zygotic animal and vegetal poles.Development, growth & differentiation · 2012Article
- Control of cytoplasmic mRNA localization.Cellular and molecular life sciences : CMLS · 2012Review
- Identification of nucleotide patterns enriched in secreted RNAs as putative cis-acting elements targeting them to exosome nano-vesicles.BMC genomics · 2011Article
- Conservation defines functional motifs in the squint/nodal-related 1 RNA dorsal localization element.Nucleic acids research · 2011Article
- A'-form RNA helices are required for cytoplasmic mRNA transport in Drosophila.Nature structural & molecular biology · 2010Article
- Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor.Genes & development · 2009Article
- Cis-acting determinants of asymmetric, cytoplasmic RNA transport.RNA (New York, N.Y.) · 2007Review
- An AU-rich stem-loop structure is a critical feature of the perinuclear localization signal of c-myc mRNA.The Biochemical journal · 2005Article
- Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Identification of a conserved RNA motif essential for She2p recognition and mRNA localization to the yeast bud.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Localization signals are RNA regulatory elements that direct the localization of mRNAs to subcellular sites. Localization signals presumably function by mediating RNA recognition events through which the mRNA becomes associated with the localization machinery. At present little is known about individual RNA recognition events, which in turn has limited progress in identifying the trans-acting binding factors involved in these events. Here we describe a detailed characterization of the RNA elements required for the RNA recognition event, event A, that initiates localization of bicoid mRNA in the Drosophila ovary. One element is a helix in which nucleotide identities are not important, suggesting that it plays a primarily structural role. Immediately adjacent to the helix is a recognition domain in which the identities of some, but not all, nucleotides are important for function. Comparison of two related but different RNAs that both support recognition event A further defines the important features of the recognition domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.