ArticleMolecular and cellular biology1998
Differential effects of protein kinase A on Ras effector pathways.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- Signal control through Raf: in sickness and in health.Cell research · 2012Review
- Ral activation promotes melanomagenesis.Oncogene · 2010Article
- Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin.Molecular pharmacology · 2009Article
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- Downregulation of Rap1GAP contributes to Ras transformation.Molecular and cellular biology · 2007Article
- The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals.Oncogene · 2007Article
- HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.Journal of molecular medicine (Berlin, Germany) · 2006Article
- Mutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways.Oncogene · 2004Article
- On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.Molecular and cellular biology · 2002Article
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- Article
- Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.Molecular and cellular biology · 2001Article
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- The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.Oncogene · 2000Article
- Cyclic AMP activates Ras.Oncogene · 2000Article
- PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS.Oncogene · 2000Article
- Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation.Oncogene · 2000Article
- RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation.Oncogene · 2000Article
- A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase.The Journal of cell biology · 1999Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Ras mutants with the ability to interact with different effectors have played a critical role in the identification of Ras-dependent signaling pathways. We used two mutants, RasS35 and RasG37, which differ in their ability to bind Raf-1, to examine Ras-dependent signaling in thyroid epithelial cells. Wistar rat thyroid cells are dependent upon thyrotropin (TSH) for growth. Although TSH-stimulated mitogenesis requires Ras, TSH activates protein kinase A (PKA) and downregulates signaling through Raf and the mitogen-activated protein kinase (MAPK) cascade. Cells expressing RasS35, a mutant which binds Raf, or RasG37, a mutant which binds RalGDS, exhibited TSH-independent proliferation. RasS35 stimulated morphological transformation and anchorage-independent growth. RasG37 stimulated proliferation but not transformation as measured by these indices. TSH exerted markedly different effects on the Ras mutants and transiently repressed MAPK phosphorylation in RasS35-expressing cells. In contrast, TSH stimulated MAPK phosphorylation and growth in cells expressing RasG37. The Ras mutants, in turn, exerted differential effects on TSH signaling. RasS35 abolished TSH-stimulated changes in cell morphology and thyroglobulin expression, while RasG37 had no effect on these activities. Together, the data indicate that cross talk between Ras and PKA discriminates between distinct Ras effector pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.