ArticleMolecular and cellular biology1998
Role of histone H1 as an architectural determinant of chromatin structure and as a specific repressor of transcription on Xenopus oocyte 5S rRNA genes.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 81 citations in OpenAlex.
- Nucleosome Positioning on Episomal Human Papillomavirus DNA in Cultured Cells.Pathogens (Basel, Switzerland) · 2021Article
- Emerging roles of linker histones in regulating chromatin structure and function.Nature reviews. Molecular cell biology · 2018Review
- Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters.The EMBO journal · 2016Article
- Chaperone-mediated chromatin assembly and transcriptional regulation in Xenopus laevis.The International journal of developmental biology · 2016Review
- Small ubiquitin-like modifier (SUMO)-mediated repression of the Xenopus Oocyte 5 S rRNA genes.The Journal of biological chemistry · 2014Article
- Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2.Nucleic acids research · 2014Article
- Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency.Epigenetics · 2012Article
- Geographic patterns of histone H1 encoding genes allelic variation in Aegilops tauschii Coss. (Poaceae).Molecular biology reports · 2012Article
- Structure of the H1 C-terminal domain and function in chromatin condensation.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2011Review
- Depletion of human histone H1 variants uncovers specific roles in gene expression and cell growth.PLoS genetics · 2008Article
- Article
- Human SWI/SNF drives sequence-directed repositioning of nucleosomes on C-myc promoter DNA minicircles.Biochemistry · 2007Article
- Tax abolishes histone H1 repression of p300 acetyltransferase activity at the human T-cell leukemia virus type 1 promoter.Journal of virology · 2006Article
- Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.The EMBO journal · 2005Article
- Differential in vivo binding dynamics of somatic and oocyte-specific linker histones in oocytes and during ES cell nuclear transfer.Molecular biology of the cell · 2005Article
- Histone mRNAs do not accumulate during S phase of either mitotic or endoreduplicative cycles in the chordate Oikopleura dioica.Molecular and cellular biology · 2004Article
- Restricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes.Molecular and cellular biology · 2004Article
- HMG-D and histone H1 alter the local accessibility of nucleosomal DNA.Nucleic acids research · 2003Article
- Histone H1 enhances synergistic activation of the MMTV promoter in chromatin.The EMBO journal · 2003Article
- Reconstitution of enhancer function in paternal pronuclei of one-cell mouse embryos.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explore the role of histone H1 as a DNA sequence-dependent architectural determinant of chromatin structure and of transcriptional activity in chromatin. The Xenopus laevis oocyte- and somatic-type 5S rRNA genes are differentially transcribed in embryonic chromosomes in vivo depending on the incorporation of somatic histone H1 into chromatin. We establish that this effect can be reconstructed at the level of a single nucleosome. H1 selectively represses oocyte-type 5S rRNA genes by directing the stable positioning of a nucleosome such that transcription factors cannot bind to the gene. This effect does not occur on the somatic-type genes. Histone H1 binds to the 5' end of the nucleosome core on the somatic 5S rRNA gene, leaving key regulatory elements in the promoter accessible, while histone H1 binds to the 3' end of the nucleosome core on the oocyte 5S rRNA genes, specifically blocking access to a key promoter element (the C box). TFIIIA can bind to the somatic 5S rRNA gene assembled into a nucleosome in the presence of H1. Because H1 binds with equivalent affinities to nucleosomes containing either gene, we establish that it is the sequence-selective assembly of a specific repressive chromatin structure on the oocyte 5S rRNA genes that accounts for differential transcriptional repression. Thus, general components of chromatin can determine the assembly of specific regulatory nucleoprotein complexes.
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