ArticleThe Journal of biological chemistry1998
Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast.
Article in The Journal of biological chemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 139 citations in OpenAlex.
- Developmental changes in nuclear lamina components during germ cell differentiation.Nucleus (Austin, Tex.) · 2024Article
- Box C/D guide RNAs recognize a maximum of 10 nt of substrates.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Review
- Ribosome biogenesis in the yeast Saccharomyces cerevisiae.Genetics · 2013Review
- The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis.Developmental biology · 2011Article
- Structures of ribonucleoprotein particle modification enzymes.Quarterly reviews of biophysics · 2011Review
- Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle.Molecular cell · 2010Article
- A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.Molecular cell · 2010Article
- BUD22 affects Ty1 retrotransposition and ribosome biogenesis in Saccharomyces cerevisiae.Genetics · 2010Article
- Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae.Molecular and cellular biochemistry · 2010Article
- Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins.BMC genomics · 2008Article
- Post-harvest regulated gene expression and splicing efficiency in storage roots of sugar beet (Beta vulgaris L.).Planta · 2008Article
- Inactivation of cleavage factor I components Rna14p and Rna15p induces sequestration of small nucleolar ribonucleoproteins at discrete sites in the nucleus.Molecular biology of the cell · 2008Article
- Elucidating the role of C/D snoRNA in rRNA processing and modification in Trypanosoma brucei.Eukaryotic cell · 2008Article
- Nop9 is an RNA binding protein present in pre-40S ribosomes and required for 18S rRNA synthesis in yeast.RNA (New York, N.Y.) · 2007Article
- The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4.RNA (New York, N.Y.) · 2007Article
- Pre-mRNA splicing and retinitis pigmentosa.Molecular vision · 2006Review
- Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D snoRNPs.Molecular and cellular biology · 2006Article
- Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast.RNA (New York, N.Y.) · 2005Article
- Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs.RNA (New York, N.Y.) · 2004Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have identified a novel nucleolar protein, Nop5p, that is essential for growth in Saccharomyces cerevisiae. Monoclonal antibodies B47 and 37C12 recognize Nop5p, which has a predicted size of 57 kDa and possesses a KKX repeat motif at its carboxyl terminus. Truncations that removed the KKX motif were functional and localized to the nucleolus, but conferred slow growth at 37 degreesC. Nop5p shows significant sequence homology with yeast Sik1p/Nop56p, and putative homologues in archaebacteria, plants, and human. Depletion of Nop5p in a GAL-NOP5 strain lengthened the doubling time about 5-fold, and selectively reduced steady-state levels of 40 S ribosomal subunits and 18 S rRNA relative to levels of free 60 S subunits and 25 S rRNA. Northern blotting and primer extension analyses showed that Nop5p depletion impairs processing of 35 S pre-rRNA at the A0 and A2 cleavage sites. Nop5p is associated with the small nucleolar RNAs U3, snR13, U14, and U18. Depletion of Nop5p caused the nucleolar protein Nop1p (yeast fibrillarin) to be localized to the nucleus and cytosol. Also, 37C12 co-immunoprecipitated Nop1p. These results suggest that Nop5p functions with Nop1p in the execution of early pre-rRNA processing steps that lead to formation of 18 S rRNA.
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