ArticleInfection and immunity1998
Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P. carinii pneumonia.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- The Major Surface Glycoprotein of Pneumocystis murina Does Not Activate Dendritic Cells.The Journal of infectious diseases · 2018Article
- Recombinant outer membrane protein Q and putative lipoprotein from Bordetella pertussis inducing strong humoral response were not protective alone in the murine lung colonization model.Turkish journal of biology = Turk biyoloji dergisi · 2018Article
- Overcoming Hurdles to Development of a Vaccine against Pneumocystis jirovecii.Infection and immunity · 2017Article
- Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii.Infection and immunity · 2017Article
- Article
- Oral Immunization of Mice with Live Pneumocystis murina Protects against Pneumocystis Pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Humoral immune responses to Pneumocystis jirovecii antigens in HIV-infected and uninfected young children with pneumocystis pneumonia.PloS one · 2013Article
- Discordant antibody and cellular responses to Pneumocystis major surface glycoprotein variants in mice.BMC immunology · 2012Article
- Relationship of Pneumocystis jiroveci humoral immunity to prevention of colonization and chronic obstructive pulmonary disease in a primate model of HIV infection.Infection and immunity · 2010Article
- Pneumocystis colonization in immunocompetent and simian immunodeficiency virus-infected cynomolgus macaques.The Journal of infectious diseases · 2009Article
- Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen.Infection and immunity · 2006Article
- Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA.Infection and immunity · 2004Article
- Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice.Infection and immunity · 2003Article
- CD4+ T cell-independent vaccination against Pneumocystis carinii in mice.The Journal of clinical investigation · 2001Article
- Genetics of surface antigen expression in Pneumocystis carinii.Infection and immunity · 2001Review
- Immunological features of Pneumocystis carinii infection in humans.Clinical and diagnostic laboratory immunology · 1999Review
- Intranasal immunization confers protection against murine Pneumocystis carinii lung infection.Infection and immunity · 1999Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Immunization with whole Pneumocystis carinii has been shown to protect mice from the development of P. carinii pneumonia (PCP) when they are subsequently immunosuppressed and challenged with viable organisms. To determine whether these results could be duplicated by using a subunit vaccine, we examined the immunogenicity and efficacy of an immunization strategy based on P. carinii gpA. This antigen was chosen for study because passive immunoprophylaxis, based on gpA, has been shown to be partially protective in various animal models of infection. Immunization with gpA produced an anti-gpA specific antibody response comparable to that resulting from immunization with whole organisms. However, in contrast to immunization with whole P. carinii, which was protective, immunization with gpA did not protect T-cell-depleted mice from the development of PCP. These studies suggest that other antigens in addition to gpA need to be evaluated for their role in protective immunity against P. carinii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.