ReviewNature biotechnology1996
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis.
Review in Nature biotechnology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 268 citations in OpenAlex.
- Advances in the application of logic gates in nanozymes.Analytical and bioanalytical chemistry · 2024Review
- Article
- Chronic Upregulation of Cleaved-Caspase-3 Associated with Chronic Myelin Pathology and Microvascular Reorganization in the Thalamus after Traumatic Brain Injury in Rats.International journal of molecular sciences · 2018Article
- Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4.PloS one · 2014Article
- Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis.Experimental and therapeutic medicine · 2013Article
- Implication of caspase-3 and granzyme B expression and activity in spleenocytes of ehrlich ascites carcinoma mice subjected to immunotherapy.North American journal of medical sciences · 2011Article
- A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.Science signaling · 2010Article
- Noninvasive imaging of apoptosis and its application in cancer therapeutics.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Monitoring caspase activity in living cells using fluorescent proteins and flow cytometry.The American journal of pathology · 2004Article
- A novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness score.BMC pharmacology · 2004Article
- Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival.Cell stress & chaperones · 2004Article
- Proteases associated with programmed cell death of megagametophyte cells after germination of white spruce (Picea glauca) seeds.Plant molecular biology · 2003Article
- Mechanisms of apoptosis.The American journal of pathology · 2000Article
- Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells.Molecular biology of the cell · 2000Article
- HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Oligodendrocyte apoptosis mediated by caspase activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors.The EMBO journal · 1999Article
- HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation.The Journal of clinical investigation · 1998Article
- Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis.Molecular and cellular biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive or failed apoptosis is a prominent morphological feature of several human diseases. Many of the key biochemical players that contribute to the highly ordered process of apoptotic cell death have recently been identified. These include members of the emerging family of cysteine proteases related to mammalian interleukin-1 beta converting enzyme (ICE) and to CED-3, the product of a gene that is necessary for programmed cell death in the nematode C. elegans. Among a growing number of potential molecular targets for the control of human diseases where inappropriate apoptosis is prominent, ICE/CED-3-like proteases may be an attractive and tangible point for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.