ArticleNucleic acids research1998
Forum domain in Drosophila melanogaster cut locus possesses looped domains inside.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- CBP and RAD21 Proteins Bind at the Termini of Forum Domains in Human Chromosomes.Doklady. Biochemistry and biophysics · 2023Article
- Genes Possessing the Most Frequent DNA DSBs Are Highly Associated with Development and Cancers, and Essentially Overlap with the rDNA-Contacting Genes.International journal of molecular sciences · 2022Article
- Interstitial telomeric repeats-associated DNA breaks.Nucleus (Austin, Tex.) · 2017Article
- Genome-wide mapping of hot spots of DNA double-strand breaks in human cells as a tool for epigenetic studies and cancer genomics.Genomics data · 2015Article
- Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation.Journal of molecular cell biology · 2015Article
- Mapping of genomic double-strand breaks by ligation of biotinylated oligonucleotides to forum domains: Analysis of the data obtained for human rDNA units.Genomics data · 2015Article
- Genome-wide profiling of forum domains in Drosophila melanogaster.Nucleic acids research · 2011Article
- Functional analysis of boundary regions of forum domains.Doklady. Biochemistry and biophysicsArticle
- Study of distant interactions of LCR from the Drosophila melanogaster locus CUT.Doklady. Biochemistry and biophysicsArticle
- Functional analysis of LCR sequences from the cut locus of Drosophila melanogaster.Doklady. Biochemistry and biophysicsArticle
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Authors and funding
5 authors.
Funding
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Abstract
We have studied the relationship between chromosomal forum domains and looped domains in the cut locus of Drosophila melanogaster . Forum domains were earlier detected by separation in pulsed-field gels of 50-150 kb chromosomal DNA fragments obtained after spontaneous non-random degradation of chromosomes. We have localized the boundary region where cleavage sites are scattered between two forum domains in the regulatory region of the cut locus. We have sequenced a 13 kb region spanning few kilobases from distal domain, the boundary region and part of the proximal forum domain where several scaffold associated regions (SARs) were observed. We conclude that forum domains and looped domains are physically different types of domains and belong to different levels of organization in eukaryotic chromosomes. The boundary region between the neighboring forum domains in the cut locus possesses the Doc element insertion and a micro-satellite stretch and thus might remind a small island of heterochromatin and correspond to so-called intercalary heterochromatin that is known to be located in the 7B1-2 band where the major part of the cut locus is reside.
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