ArticleNucleic acids research1998
U2 and U6 snRNA genes in the microsporidian Nosema locustae: evidence for a functional spliceosome.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- The LncRNA Expression Profile and Regulatory Network of Microsporidian During the Infection of Western Honeybee.Animals : an open access journal from MDPI · 2026Article
- Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts.RNA (New York, N.Y.) · 2007Article
- Free energy landscapes of RNA/RNA complexes: with applications to snRNA complexes in spliceosomes.Journal of molecular biology · 2006Article
- Rates of intron loss and gain: implications for early eukaryotic evolution.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Complex early genes.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Mystery of intron gain.Genome research · 2003Article
- Large-scale comparison of intron positions among animal, plant, and fungal genes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).Genome research · 2001Article
- Coupled nucleotide covariations reveal dynamic RNA interaction patterns.RNA (New York, N.Y.) · 2000Review
- Molecular techniques for detection, species differentiation, and phylogenetic analysis of microsporidia.Clinical microbiology reviews · 1999Review
- Microsporidia are related to Fungi: evidence from the largest subunit of RNA polymerase II and other proteins.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The removal of introns from pre-messenger RNA is mediated by the spliceosome, a large complex composed of many proteins and five small nuclear RNAs (snRNAs). Of the snRNAs, the U6 and U2 snRNAs are the most conserved in sequence, as they interact extensively with each other and also with the intron, in several base pairings that are necessary for splicing. We have isolated and sequenced the genes encoding both U6 and U2 snRNAs from the intracellularly parasitic microsporidian Nosema locustae . Both genes are expressed. Both RNAs can be folded into secondary structures typical of other known U6 and U2 snRNAs. In addition, the N.locustae U6 and U2 snRNAs have the potential to base pair in the functional intermolecular interactions that have been characterized by extensive analyses in yeast and mammalian systems. These results indicate that the N.locustae U6 and U2 snRNAs may be functional components of an active spliceosome, even though introns have not yet been found in microsporidian genes.
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