ArticleNucleic acids research1998
Meiotic role of SWI6 in Saccharomyces cerevisiae.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Insights into the identification and evolutionary conservation of key genes in the transcriptional circuits of meiosis initiation and commitment in budding yeast.FEBS open bio · 2023Article
- PKC-SWI6 signaling regulates asexual development, cell wall integrity, stress response, and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora.Science China. Life sciences · 2022Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork.Genome research · 2019Article
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- Article
- Yeast IME2 functions early in meiosis upstream of cell cycle-regulated SBF and MBF targets.PloS one · 2012Article
- The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell size.PLoS genetics · 2009Article
- A probabilistic generative model for GO enrichment analysis.Nucleic acids research · 2008Article
- Classifying transcription factor targets and discovering relevant biological features.Biology direct · 2008Article
- Article
- DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.Molecular genetics and genomics : MGG · 2004Article
- DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts.The Biochemical journal · 2000Review
- CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast.Molecular and cellular biology · 2000Article
- A nonessential HP1-like protein affects starvation-induced assembly of condensed chromatin and gene expression in macronuclei of Tetrahymena thermophila.Molecular and cellular biology · 1999Article
- Modelling gene regulation networks via multivariate adaptive splines.Cancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcript levels of DNA replication genes and some recombination genes in Saccharomyces cerevisiae fluctuate and peak at the G1/S boundary in the mitotic cell cycle. This fluctuation is regulated by MCB (Mlu I cell cycle box) elements which are bound by the DSC1/MBF1 complex consisting of Swi6 and Mbp1. It is also known that some of the MCB-regulated genes are induced by treatment with DNA damaging agents and in meiosis. In this report, the function of SWI6 in meiosis was investigated. Delta swi6 cells underwent sporulation as did wild-type cells. However, the deletion mutant cells showed reduced spore viability and lower frequency of recombination. The transcript levels of the recombination genes RAD51 and RAD54 , which have MCB elements, were reduced in Delta swi6 cells. The transcript levels of SWI6 itself were also induced and declined in meiosis. Furthermore, an increased dosage of SWI6 enhanced the transcript level of the RAD51 gene and also the recombination frequency in meiosis. These results suggest that SWI6 enhances the expression level of the recombination genes in meiosis in a dosage-dependent manner, which results in an effect on the frequency of meiotic recombination.
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