ArticleNucleic acids research1998
A single nucleotide change in the c-myc internal ribosome entry segment leads to enhanced binding of a group of protein factors.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Integrating rna structure and protein interactions to uncover the mechanisms of viral and cellular ires function.Biology direct · 2025Article
- MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells.Cell death discovery · 2023Article
- Annexin A2 binds the internal ribosomal entry site of c-RNA biology · 2021Article
- Evolutionary-driven C-MYC gene expression in mammalian fibroblasts.Scientific reports · 2020Article
- Exploring the Impact of Single-Nucleotide Polymorphisms on Translation.Frontiers in genetics · 2018Review
- Genome-wide search for exonic variants affecting translational efficiency.Nature communications · 2013Article
- Article
- Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.Molecular and cellular biology · 2008Article
- Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression.Oncogene · 2004Review
- Article
- Article
- Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment.Nucleic acids research · 2000Article
- Internal ribosome entry sites (IRESs): reality and use.Transgenic research · 1999Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 340 nucleotide section of the c- myc 5' untranslated region (UTR) contains an internal ribosome entry segment. We have described previously a mutation in this region of RNA in cell lines derived from patients with multiple myeloma (MM) which exhibit increased expression of c- myc protein by an aberrant translational mechanism. In this study we show by electrophoretic mobility shift assays (EMSA), north-western blotting and UV cross-linking that radiolabelled c- myc 5' UTR RNA transcripts which harbour the mutation cause enhanced binding of cellular proteins. In addition, we also demonstrate that an MM derived cell line possesses an altered repertoire of RNA binding proteins. Our data suggest that the deregulated expression of c -myc in MM could result both from the effect of the mutation and the additional proteins which are present in these cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.