ArticleThe Journal of cell biology1998
A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Pathological calcium overload impairs skeletal muscle regeneration through sustained NFAT-dependent proliferative signaling.Experimental & molecular medicine · 2026Article
- Skeletal Ryanodine Receptors Are Involved in Impaired Myogenic Differentiation in Duchenne Muscular Dystrophy Patients.International journal of molecular sciences · 2021Article
- Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation.Cold Spring Harbor perspectives in biology · 2020Review
- Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.Developmental cell · 2018Article
- Organelle Optogenetics: Direct Manipulation of Intracellular CaFrontiers in neuroscience · 2018Article
- Chaperones and the Proteasome System: Regulating the Construction and Demolition of Striated Muscle.International journal of molecular sciences · 2017Review
- CaDevelopmental biology · 2017Article
- Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscleDevelopment (Cambridge, England) · 2017Article
- Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.Scientific reports · 2017Article
- Review
- Contractile activity is required for Z-disc sarcomere maturation in vivo.Genesis (New York, N.Y. : 2000) · 2015Article
- Spontaneous calcium transients manifest in the regenerating muscle and are necessary for skeletal muscle replenishment.Cell calcium · 2014Article
- Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells.PloS one · 2012Article
- Stem cells and calcium signaling.Advances in experimental medicine and biology · 2012Review
- At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis.Biochemistry research international · 2012Article
- Visualization of Ca²+ signaling during embryonic skeletal muscle formation in vertebrates.Cold Spring Harbor perspectives in biology · 2011Review
- How to build a myofibril.Journal of muscle research and cell motility · 2005Article
- Complete human gene structure of obscurin: implications for isoform generation by differential splicing.Journal of muscle research and cell motility · 2005Article
- Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Contribution of ryanodine receptor type 3 to Ca(2+) sparks in embryonic mouse skeletal muscle.Biophysical journal · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous calcium release from intracellular stores occurs during myofibrillogenesis, the process of sarcomeric protein assembly in striated muscle. Preventing these Ca2+ transients disrupts sarcomere formation, but the signal transduction cascade has not been identified. Here we report that specific blockade of Ca2+ release from the ryanodine receptor (RyR) activated Ca2+ store blocks transients and disrupts myosin thick filament (A band) assembly. Inhibition of an embryonic Ca2+/calmodulin-dependent myosin light chain kinase (MLCK) by blocking the ATP-binding site, by allosteric phosphorylation, or by intracellular delivery of a pseudosubstrate peptide, also disrupts sarcomeric organization. The results indicate that both RyRs and MLCK, which have well-described calcium signaling roles in mature muscle contraction, have essential developmental roles during construction of the contractile apparatus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.