ReviewMolecular neurobiology1998
Drugs of abuse and immediate-early genes in the forebrain.
Review in Molecular neurobiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 196 citations in OpenAlex.
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- Individual differences in cocaine-induced conditioned place preference in male rats: Behavioral and transcriptomic evidence.Journal of psychopharmacology (Oxford, England) · 2022Article
- Identification and Verification of Potential Hub Genes in Amphetamine-Type Stimulant (ATS) and Opioid Dependence by Bioinformatic Analysis.Frontiers in genetics · 2022Article
- Angiogenic gene networks are dysregulated in opioid use disorder: evidence from multi-omics and imaging of postmortem human brain.Molecular psychiatry · 2021Article
- From Pleasure to Pain, and Back Again: The Intricate Relationship Between Alcohol and Nociception.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Review
- Immediate early genes in social insects: a tool to identify brain regions involved in complex behaviors and molecular processes underlying neuroplasticity.Cellular and molecular life sciences : CMLS · 2019Review
- HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.Neuron · 2017Article
- Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Region-specific effects of isoflurane anesthesia on Fos immunoreactivity in response to intravenous cocaine challenge in rats with a history of repeated cocaine administration.Brain research · 2015Article
- Effects of acute and chronic inhalation of paint thinner in mice: behavioral and immunohistochemical study.Metabolic brain disease · 2014Article
- Prefrontal cortical and striatal transcriptional responses to the reinforcing effect of repeated methylphenidate treatment in the spontaneously hypertensive rat, animal model of attention-deficit/hyperactivity disorder (ADHD).Behavioral and brain functions : BBF · 2014Article
- Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum.BMC genomics · 2013Article
- A role for the prefrontal cortex in heroin-seeking after forced abstinence by adult male rats but not adolescents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Electroacupuncture reduces cocaine-induced seizures and mortality in mice.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Addiction-related gene regulation: risks of exposure to cognitive enhancers vs. other psychostimulants.Progress in neurobiology · 2013Review
- 5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen.Synapse (New York, N.Y.) · 2012Article
- Effect of Sevoflurane postconditioning on gene expression in brain tissue of the middle cerebral artery occlusion rat model.Molecular biology reports · 2012Article
- Novel cues reinstate cocaine-seeking behavior and induce Fos protein expression as effectively as conditioned cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Activation of mu opioid receptors in the striatum differentially augments methamphetamine-induced gene expression and enhances stereotypic behavior.Journal of neurochemistry · 2012Article
- Regulation of the immediate-early genes arc and zif268 in a mouse operant model of cocaine seeking reinstatement.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A diverse array of chemical agents have been self administered by humans to alter the psychological state. Such drugs of abuse include both stimulants and depressants of the central nervous system. However, some commonalties must underlie the neurobiological actions of these drugs, since the desire to take the drugs often crosses from one drug to another. Studies have emphasized a role of the ventral striatum, especially the nucleus accumbens, in the actions of all drugs of abuse, although more recent studies have implicated larger regions of the forebrain. Induction of immediate-early genes has been studied extensively as a marker for activation of neurons in the central nervous system. In this review, we survey the literature reporting activation of immediate-early gene expression in the forebrain, in response to administration of drugs of abuse. All drugs of abuse activate immediate-early gene expression in the striatum, although each drug induces a particular neuroanatomical signature of activation. Most drugs of abuse activate immediate-early gene expression in several additional forebrain regions, including portions of the extended amygdala, cerebral cortex, lateral septum, and midline/intralaminar thalamic nuclei, although regional variations are found depending on the particular drug administered. Common neuropharmacological mechanisms responsible for activation of immediate-early gene expression in the forebrain involve dopaminergic and glutamatergic systems. Speculations on the biological significance and clinical relevance of immediate-early gene expression in response to drugs of abuse are presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.