ArticleThe American journal of pathology1998
Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airways.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
- Neutrophil serine proteases degrade endothelial cortactin and promote extravasation.The Journal of cell biology · 2026Article
- Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation.Acta physiologica (Oxford, England) · 2025Review
- Conditions that promote transcellular neutrophil migration in vivo.Scientific reports · 2024Article
- Csk controls leukocyte extravasation via local regulation of Src family kinases and cortactin signaling.Frontiers in immunology · 2024Article
- Pathological hemodynamic changes and leukocyte transmigration disrupt the blood-spinal cord barrier after spinal cord injury.Journal of neuroinflammation · 2023Article
- Membrane curvature and PS localize coagulation proteins to filopodia and retraction fibers of endothelial cells.Blood advances · 2023Article
- Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1.EMBO reports · 2023Article
- Transendothelial migration induces differential migration dynamics of leukocytes in tissue matrix.Journal of cell science · 2021Article
- Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2.Blood · 2020Article
- Local microvascular leakage promotes trafficking of activated neutrophils to remote organs.The Journal of clinical investigation · 2020Article
- Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions.Cellular and molecular bioengineering · 2020Article
- Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Oxidative Stress and Microvessel Barrier Dysfunction.Frontiers in physiology · 2020Review
- Airways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma.The Journal of allergy and clinical immunology · 2019Review
- Endothelial cells in the innate response to allergens and initiation of atopic asthma.The Journal of clinical investigation · 2018Article
- Sensing of Vascular Permeability in Inflamed Vessel of Live Animal.Journal of analytical methods in chemistry · 2018Article
- Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.JCI insight · 2017Article
- Leukocyte transendothelial migration: A local affair.Small GTPases · 2017Review
- How monocytes guard the glomerulus.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Transendothelial migration: unifying principles from the endothelial perspective.Immunological reviews · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Exposure of sensitized individuals to antigen can induce allergic responses in the respiratory tract, manifested by early and late phases of vasodilatation, plasma leakage, leukocyte influx, and bronchoconstriction. Similar responses can occur in the skin, eye, and gastrointestinal tract. The early-phase response involves mast cell mediators and the late-phase response is leukocyte dependent, but the mechanism of leakage is not understood. We sought to identify the leaky blood vessels, to determine whether these vessels contained endothelial gaps, and to analyze the relationship of the gaps to adherent leukocytes, using biotinylated lectins or silver nitrate to stain the cells in situ and Monastral blue as a tracer to quantify plasma leakage. Most of the leakage occurred in postcapillary venules (< 40-microns diameter), whereas most of the leukocyte migration (predominantly neutrophils) occurred in collecting venules. Capillaries and arterioles did not leak. Endothelial gaps were found in the leaky venules, both by silver nitrate staining and by scanning electron microscopy, and 94% of the gaps were distinct from sites of leukocyte adhesion or migration. We conclude that endothelial gaps contribute to both early and late phases of plasma leakage induced by antigen, but most leakage occurs upstream to sites of leukocyte adhesion.
Indexed as
Identifiers
9626051PMC1858452W2203045174What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.