ArticleThe Journal of physiology1998
Importance of basolateral K+ conductance in maintaining Cl- secretion in murine nasal and colonic epithelia.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 82 citations in OpenAlex.
- Potassium Channels of the Airway Epithelium.Acta physiologica (Oxford, England) · 2026Review
- The effect of claudin-15 deletion on cationic selectivity and transport in paracellular pathways of the cecum and large intestine.Scientific reports · 2023Article
- Flupirtine enhances NHE-3-mediated NaAmerican journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Activation ofAmerican journal of physiology. Cell physiology · 2021Article
- KThe Journal of physiology · 2018Article
- Secretory diarrhoea: mechanisms and emerging therapies.Nature reviews. Gastroenterology & hepatology · 2015Review
- Natural selection in a bangladeshi population from the cholera-endemic ganges river delta.Science translational medicine · 2013Article
- Benzimidazolones enhance the function of epithelial Na⁺ transport.British journal of pharmacology · 2013Article
- Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?ChemMedChem · 2012Review
- Mucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.PloS one · 2011Article
- Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.The Journal of biological chemistry · 2010Article
- Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells.American journal of physiology. Cell physiology · 2009Article
- Multiple KCNQ potassium channel subtypes mediate basal anion secretion from the human airway epithelial cell line Calu-3.The Journal of membrane biology · 2008Article
- A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel.The Journal of physiology · 2004Article
- Heartburn: cardiac potassium channels involved in parietal cell acid secretion.Pflugers Archiv : European journal of physiology · 2003Review
- Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon.The Journal of physiology · 2002Article
- Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.The Journal of physiology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
1. Epithelia lining the nasal passages and descending colon of wild-type and cystic fibrosis (CF) mice were examined by the short-circuit current technique. Additionally, intracellular Ca2+ ion determinations were made in nasal epithelial cells. Forskolin produced anion secretory currents in wild-type and CF nasal epithelia. It produced similar effects in wild-type colonic epithelia, but not in colonic epithelia from CF mice. 2. After electrogenic Na+ transport was blocked with amiloride and electrogenic Cl- secretion was stimulated with forskolin, the ability of K+ channel blockers to inhibit the forskolin-induced Cl- current was determined. The order of efficiency for nasal epithelium was: Ba2+ > clofilium >>> TEA = azimilide >>> trans-6-cyano-4-(N-ethylsulphonyl-N-methylamino)-3-hydroxy-2, 2-dimethyl-chromane (293B) = charybdotoxin, whereas for the colonic epithelium the order was: Ba2+ = 293B >>> azimilide = TEA >>> clofilium = charybdotoxin. 3. 1-Ethyl-2-benzimdazolinone (1-EBIO) was able to generate large Cl--secretory currents in colonic epithelia which were partially sensitive to charybdotoxin, with the remaining current being inhibited by 293B. In nasal epithelia 1-EBIO produced only a small transient effect on current. 4. Forskolin released intracellular Ca2+ in nasal epithelial cells; this activity was attenuated when more powerful Ca2+-releasing agents were applied first. 5. It is concluded that an action on basolateral cAMP-sensitive K+ channels is an important determinant of the maintained responses to forskolin in nasal and colonic epithelia, in addition to the effects on the cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane. In CF nasal epithelia the activation of calcium-activated chloride channels (CACs) substitutes for the effect on CFTR. On the basis of the different orders of potency of the blocking agents and the differential response to 1-EBIO it is concluded that the cAMP-sensitive K+ channels are different in the airways and the gut.
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