ArticleThe Journal of physiology1998
Mathematical model of vertebrate gap junctions derived from electrical measurements on homotypic and heterotypic channels.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Membrane voltage multistability in coupled glial cells.bioRxiv : the preprint server for biology · 2026Article
- Innate Orientating Behavior of a Multi-Legged Robot Driven by the Neural Circuits ofBiomimetics (Basel, Switzerland) · 2024Article
- Modeling and analysis of voltage gating of gap junction channels at a single-channel level.Biophysical journal · 2023Article
- Coupling between cardiac cells-An important determinant of electrical impulse propagation and arrhythmogenesis.Biophysics reviews · 2021Review
- Four-State Model for Simulating Kinetic and Steady-State Voltage-Dependent Gating of Gap Junctions.Biophysical journal · 2020Article
- Non-ohmic tissue conduction in cardiac electrophysiology: Upscaling the non-linear voltage-dependent conductance of gap junctions.PLoS computational biology · 2020Article
- Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Computational Model of Coupled Myocytes.Frontiers in physiology · 2020Article
- Properties of cardiac conduction in a cell-based computational model.PLoS computational biology · 2019Article
- Gap junctional signaling in pattern regulation: Physiological network connectivity instructs growth and form.Developmental neurobiology · 2017Review
- Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating.PLoS computational biology · 2017Article
- Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp.Biophysical journal · 2016Article
- Stochastic Model of Gap Junctions Exhibiting Rectification and Multiple Closed States of Slow Gates.Biophysical journal · 2016Article
- Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels.The Journal of general physiology · 2016Article
- Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis.BioMed research international · 2015Review
- Alterations in gap junction connexin43/connexin45 ratio mediate a transition from quiescence to excitation in a mathematical model of the myometrium.Journal of the Royal Society, Interface · 2014Article
- Heterotypic connexin50/connexin50 mutant gap junction channels reveal interactions between two hemichannels during transjunctional voltage-dependent gating.The Journal of physiology · 2012Article
- Regulation of Cx45 hemichannels mediated by extracellular and intracellular calcium.Pflugers Archiv : European journal of physiology · 2012Article
- Voltage-dependent conformational changes in connexin channels.Biochimica et biophysica acta · 2012Review
- Stochastic 16-state model of voltage gating of gap-junction channels enclosing fast and slow gates.Biophysical journal · 2012Article
- Biology and biotechnology of follicle development.TheScientificWorldJournal · 2012Review
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2 authors.
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Abstract
1. A mathematical model has been developed which describes the conductive and kinetic properties of homotypic and heterotypic gap junction channels of vertebrates. 2. The model consists of two submodels connected in series. Each submodel simulates a hemichannel and consists of two conductances corresponding to a high (H) and low (L) conductance state and a switch, which simulates the voltage-dependent channel gating. 3. It has been assumed that the conductances of the high state and low state vary exponentially with the voltage across the hemichannel. 4. The parameters of the exponentials can be derived from data of heterotypic or homotypic channels. As a result, the behaviour of heterotypic channels can be predicted from homotypic channel data and vice versa. 5. The two switches of a channel are governed by the voltage drop across the respective hemichannel. The switches of a channel work independently, thus giving rise to four conformational states, i.e. HH, LH, HL and LL. 6. The computations show that the dogma of a constant conductance for homotypic channels results from the limited physiological range of transjunctional voltages (Vj) and the kinetic properties of the channel, so a new fitting procedure is presented. 7. Simulation of the kinetic properties at the multichannel level revealed current time courses which are consistent with a contingent gating. 8. The calculations have also shown that the channel state LL is rare and of short duration, and hence easy to miss experimentally. 9. The design of the model has been kept flexible. It can be easily expanded to include additional features, such as channel substates or a closed state.
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