ArticleThe Journal of physiology1998
Caesium blocks depolarizing after-potentials and phasic firing in rat supraoptic neurones.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Endoplasmic Reticulum and Mitochondrial Calcium Handling Dynamically Shape Slow Afterhyperpolarizations in Vasopressin Magnocellular Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Functional coupling between NMDA receptors and SK channels in rat hypothalamic magnocellular neurons: altered mechanisms during heart failure.The Journal of physiology · 2021Article
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- Specificity in the interaction of high-voltage-activated CaJournal of neurophysiology · 2018Article
- Changes in potassium channel modulation may underlie afterhyperpolarization plasticity in oxytocin neurons during late pregnancy.Journal of neurophysiology · 2018Article
- A reduction in SK channels contributes to increased activity of hypothalamic magnocellular neurons during heart failure.The Journal of physiology · 2017Article
- Phosphatidylinositol 4,5-bisphosphate (PIPThe Journal of physiology · 2017Article
- Neuronal hyperexcitability in a mouse model ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Asynchronous presynaptic glutamate release enhances neuronal excitability during the post-spike refractory period.The Journal of physiology · 2016Article
- Electrophysiology of Hypothalamic Magnocellular Neurons In vitro: A Rhythmic Drive in Organotypic Cultures and Acute Slices.Frontiers in neuroscience · 2016Article
- A simple integrative electrophysiological model of bursting GnRH neurons.Journal of computational neuroscience · 2012Article
- Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs.Physiological research · 2012Article
- Performance, properties and plasticity of identified oxytocin and vasopressin neurones in vitro.Journal of neuroendocrinology · 2010Review
- Glutamatergic inputs contribute to phasic activity in vasopressin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- 17Beta-estradiol regulation of T-type calcium channels in gonadotropin-releasing hormone neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization.The Journal of physiology · 2009Article
- Dehydration increases L-type Ca(2+) current in rat supraoptic neurons.The Journal of physiology · 2007Article
- Physiologic regulation of a tetrodotoxin-sensitive sodium influx that mediates a slow afterdepolarization potential in gonadotropin-releasing hormone neurons: possible implications for the central regulation of fertility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Activity-dependent synaptic plasticity in the supraoptic nucleus of the rat hypothalamus.The Journal of physiology · 2006Article
- A novel osmosensitive voltage gated cation current in rat supraoptic neurones.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of Cs+ on the action potential, post-train after-hyperpolarization (AHP), Ca2+-dependent post-spike depolarizing after-potential (DAP) and phasic firing were examined during intracellular recordings from magnocellular neurosecretory cells (MNCs) in superfused rat hypothalamic explants. 2. Extracellular Cs+ reversibly inhibited (IC50, approximately 1 mM) DAPs, and associated after-discharges, that followed brief spike trains in each of sixteen cells tested. Although bath application of Cs+ also provoked a small reversible depolarization, inhibition of the DAP was retained when membrane voltage was kept constant by current injection. 3. Application of Cs+ had no significant effects on spike duration (n = 8), frequency-dependent spike broadening (n = 8), spike hyperpolarizing after-potentials (n = 14), or the amplitude of the isolated AHP (n = 7). Caesium-evoked inhibition of the DAP, therefore, does not result from diminished spike-evoked Ca2+ influx, and may reflect direct blockade of the conductance underlying the DAP. 4. Inhibition of the DAP was associated with an enhancement of the amplitude and duration of the AHP, indicating that the currents underlying the AHP and the DAP overlap in time following a train of action potentials, and that the relative magnitude of these currents is an important factor in determining the shape and time course of post-train after-potentials. 5. Bath application of Cs+ reversibly abolished phasic firing in each of seven cells tested. This effect was reversible and persisted at all subthreshold voltages tested. These results indicate that the current underlying the DAP is necessary for the genesis of plateau potentials and phasic firing in MNCs.
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