ArticleThe Journal of physiology1998
K+ channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 127 citations in OpenAlex.
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- The Sigma-1 Receptor: When Adaptive Regulation of Cell Electrical Activity Contributes to Stimulant Addiction and Cancer.Frontiers in neuroscience · 2019Review
- Spatial habitats from multiparametric MR imaging are associated with signaling pathway activities and survival in glioblastoma.Oncotarget · 2017Article
- Pituitary Gonadotropins, Prolactin and Growth Hormone Differentially Regulate AQP1 Expression in the Porcine Ovarian Follicular Cells.International journal of molecular sciences · 2017Article
- Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer.The Journal of membrane biology · 2017Review
- Role of aquaporins in cell proliferation: What else beyond water permeability?Channels (Austin, Tex.) · 2016Review
- Low-voltage-activated T-type Ca2+ channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin.Pflugers Archiv : European journal of physiology · 2014Review
- Up-regulation of Kv7.1 channels in thromboxane A2-induced colonic cancer cell proliferation.Pflugers Archiv : European journal of physiology · 2014Article
- Blockage of potassium channel inhibits proliferation of glioma cells via increasing reactive oxygen species.Oncology research · 2014Article
- The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.Frontiers in physiology · 2013Review
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- OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors.Human molecular genetics · 2012Article
- Eag and HERG potassium channels as novel therapeutic targets in cancer.World journal of surgical oncology · 2010Review
- From the background to the spotlight: TASK channels in pathological conditions.Brain pathology (Zurich, Switzerland) · 2010Review
- The two-pore domain potassium channel TASK3 functionally impacts glioma cell death.Journal of neuro-oncology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. A variety of studies have suggested that K+ channel activity is a key determinant for cell progression through the G1 phase of mitosis. We have previously proposed that K+ channels control the activity of cell cycle-regulating proteins via regulation of cell volume. In order to test this hypothesis, we measured, with a Coulter counter and under different experimental conditions, the volume and rate of proliferation of neuroblastoma x glioma hybrid NG108-15 cells. 2. The K+ channel blockers TEA (1-10 mM), 4-aminopyridine (0.2-2 mM) and Cs+ (2.5-10 mM) increased the cell volume and decreased the rate of cell proliferation. Proliferation was fully inhibited when cell volume was increased by 25 %. 3. A 40 % increase in the culture medium osmolarity with NaCl induced a 25 % increase in cell volume and an 82 % decrease in the rate of cell proliferation. A 40 % increase in the culture medium osmolarity with mannitol induced a 9 % increase in cell volume and a 60 % decrease in the rate of cell proliferation. 4. The Cl- channel blocker NPPB (5-nitro-2-(3-phenylpropylamino) benzoic acid; 50 microM) induced a 12 % increase in cell volume and a 77 % decrease in the rate of cell proliferation. 5. A 24 % reduction in the culture medium osmolarity with H2O induced a 21 % decrease in cell volume and a 32 % increase in the rate of cell proliferation. 6. Under whole-cell patch-clamp conditions, antibiotics (penicillin plus streptomycin) decreased the voltage-dependent K+ current. Omission of antibiotics from the culture medium induced a 10 % decrease in the cell volume and a 32 % increase in the rate of cell proliferation. 7. These results suggest that the mechanisms controlling cell proliferation are strongly influenced by the factors which determine cell volume. This could take into account the role in mitogenesis of K+ channels and of other ionic pathways involved in cell volume regulation.
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