ArticleThe Journal of physiology1998
Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 124 citations in OpenAlex.
- Article
- Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity.Cellular and molecular neurobiology · 2023Article
- Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing.International journal of molecular sciences · 2021Article
- Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Purinergic receptor expression and function in rat vagal sensory neurons innervating the stomach.Neuroscience letters · 2019Article
- Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors.Journal of bone and mineral metabolism · 2018Article
- Tonotopic action potential tuning of maturing auditory neurons through endogenous ATP.The Journal of physiology · 2017Article
- Morphology of P2X3-immunoreactive nerve endings in the rat laryngeal mucosa.Histochemistry and cell biology · 2016Article
- The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.Science translational medicine · 2015Article
- Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteins.Antioxidants & redox signaling · 2014Review
- Structural and molecular modeling features of P2X receptors.International journal of molecular sciences · 2014Review
- Principles and properties of ion flow in P2X receptors.Frontiers in cellular neuroscience · 2014Review
- Desensitization properties of P2X3 receptors shaping pain signaling.Frontiers in cellular neuroscience · 2013Review
- Two open states of P2X receptor channels.Frontiers in cellular neuroscience · 2013Review
- Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Activation and regulation of purinergic P2X receptor channels.Pharmacological reviews · 2011Review
- Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.The Journal of biological chemistry · 2011Article
- Pharmacological properties and physiological function of a P2X-like current in single proximal tubule cells isolated from frog kidney.The Journal of membrane biology · 2010Article
- Inhibition of P2X(7) receptors by divalent cations: old action and new insight.European biophysics journal : EBJ · 2009Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell recordings were made from HEK 293 (human embryonic kidney) cells stably transfected with cDNAs encoding P2X2, P2X3 or both receptors (P2X2/3) and from cultured rat nodose neurones. Nodose neurones all showed immunoreactivity for both P2X2 and P2X3, but not P2X1, receptors. 2. Reversal potentials were measured in extracellular sodium, N-methyl-D-glucamine (NMDG) and NMDG containing 5 mM Ca2+; the values were used to compute relative permeabilities (PNMDG/PNa and PCa/PNa). PNMDG/PNa was not different for P2X2, P2X2/3 and nodose neurones (0.03) but was significantly higher (0.07) for P2X3 receptors. PCa/PNa was not different among P2X3, P2X2/3 and nodose neurones (1.2-1.5) but was significantly higher (2.5) for P2X2 receptors. 3. External Ca2+ inhibited purinoceptor currents with half-maximal concentrations of 5 mM at the P2X2 receptor, 89 mM at the P2X3 receptor and 15 mM at both the P2X2/3 heteromeric receptor and nodose neurones. In each case, the inhibition was voltage independent and was overcome by increasing concentrations of agonist. 4. These results may indicate that Ca2+ permeability of the heteromeric (P2X2/3) channel is dominated by that of the P2X3 subunit, while Ca2+ block of the receptor involves both P2X2 and P2X3 subunits. The correspondence in properties between P2X2/3 receptors and nodose ganglion neurones further supports the conclusion that the native alpha,beta-methylene ATP-sensitive receptor is a P2X2/3 heteromultimer.
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