ArticleThe Journal of experimental medicine1998
Interferon enhances tumor necrosis factor-induced vascular cell adhesion molecule 1 (CD106) expression in human endothelial cells by an interferon-related factor 1-dependent pathway.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 86 citations in OpenAlex.
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- Assessment of NK cytotoxicity and interactions with porcine endothelial cells by live-cell imaging in 2D static and 3D microfluidic systems.Scientific reports · 2024Article
- Metformin synergizes with PD-1 blockade to promote normalization of tumor vessels via CD8T cells and IFNγ.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Endothelial progenitor cells in the host defense response.Pharmacology & therapeutics · 2023Review
- STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment.Journal for immunotherapy of cancer · 2021Article
- Ataxin-10 Inhibits TNF-Mediators of inflammation · 2021Article
- Specific Features of the Coagulopathy Signature in Severe COVID-19 Pneumonia.Frontiers in medicine · 2021Article
- Review
- Innate Immune Dysfunction in Rosacea Promotes Photosensitivity and Vascular Adhesion Molecule Expression.The Journal of investigative dermatology · 2020Article
- Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3.Food & nutrition research · 2019Article
- Epigallocatechin-3 Gallate InhibitsInternational journal of environmental research and public health · 2018Article
- Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation.Scientific reports · 2017Article
- Differential role of an NF-κB transcriptional response element in endothelial versus intimal cell VCAM-1 expression.Circulation research · 2015Article
- Bioavailability and molecular activities of anthocyanins as modulators of endothelial function.Genes & nutrition · 2014Article
- Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2.The Journal of experimental medicine · 2014Article
- Atherosclerosis and interferon-γ: new insights and therapeutic targets.Trends in cardiovascular medicine · 2014Review
- IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal.Circulation research · 2012Article
- Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants.Antioxidants & redox signaling · 2011Review
- Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathways.Proceedings of the American Thoracic Society · 2008Review
- Amelioration of lacrimal gland inflammation by oral administration of K-13182 in Sjögren's syndrome model mice.Clinical and experimental immunology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor (TNF) and interleukin 1 are known to initiate endothelial vascular cell adhesion molecule (VCAM)-1 transcription primarily by activating nuclear factor (NF)-kappaB, which translocates to the nucleus. In addition to two NF-kappaB elements found within the minimal cytokine-inducible VCAM-1 promoter, an interferon-related factor (IRF) element (IRF-1) has been identified close to the transcription initiation site, suggesting that cytokines that induce IRF-1 might affect VCAM-1 expression levels. We therefore investigated the effects of interferons (IFNs), which strongly induce IRF-1, on VCAM-1 transcription and expression. We show that IFN-alpha and -gamma enhance TNF-induced VCAM-1 mRNA transcription and protein expression in human endothelial cells. IFN enhancement of TNF-induced expression is also seen using chloramphenicol acetyl transferase reporter genes linked to the minimal cytokine inducible VCAM-1 promoter. Nuclear IRF-1 is the molecular basis of IFN enhancement, because (a) IFN plus TNF-treated cells displayed increased nuclear IRF-1 levels and increased IRF-1 binding to the VCAM-1 promoter, compared with cells treated with TNF alone; (b) kinetics of nuclear IRF-1 levels correlated with VCAM-1 mRNA levels; (c) transfection with an IRF-1 construct substituted for IFN treatment; and (d) transfection with an expression construct encoding IRF-2, a competitive inhibitor of IRF-1, reduced TNF-induced VCAM-1 expression. Our experiments show that IFN amplifies TNF-induced VCAM-1 expression at the transcriptional level by an IRF-1-dependent pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.