ArticleAntimicrobial agents and chemotherapy1998
Efficacies of zinc-finger-active drugs against Giardia lamblia.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- In Vitro Activities of Dithiocarbamate Derivatives againstTropical medicine and infectious disease · 2023Article
- Antigiardial Activity of Novel Guanidine Compounds.ChemMedChem · 2022Article
- Disulfiram bolsters T-cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling.The EMBO journal · 2022Article
- Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases.Anti-infective agents · 2022Article
- Direct targeted therapy for MLL-fusion-driven high-risk acute leukaemias.Clinical and translational medicine · 2022Article
- Giardia duodenalis Virulence - "To Be, or Not To Be".Current tropical medicine reports · 2021Review
- Treatment-refractory giardiasis: challenges and solutions.Infection and drug resistance · 2018Review
- Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential.International journal for parasitology. Drugs and drug resistance · 2017Article
- Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.Antimicrobial agents and chemotherapy · 2017Article
- Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions.Antimicrobial agents and chemotherapy · 2015Article
- Review
- Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.PLoS neglected tropical diseases · 2015Article
- Discovery of novel antigiardiasis drug candidates.Antimicrobial agents and chemotherapy · 2014Article
- Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram.The Journal of biological chemistry · 2014Article
- A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia.Antimicrobial agents and chemotherapy · 2013Article
- Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents.Parasitology research · 2012Article
- Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.Antimicrobial agents and chemotherapy · 2012Article
- Ascorbate and thiol antioxidants abolish sensitivity of yeast Saccharomyces cerevisiae to disulfiram.Cell biology and toxicology · 2012Article
- A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase.Current chemical genomics · 2012Article
- The genome of the blood fluke Schistosoma mansoni.Nature · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.
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