ArticleArchives of disease in childhood1998
Influence of five years of antenatal screening on the paediatric cystic fibrosis population in one region.
Article in Archives of disease in childhood, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Addressing the dark matter of gene therapy: technical and ethical barriers to clinical application.Human genetics · 2022Review
- The future of cystic fibrosis care: a global perspective.The Lancet. Respiratory medicine · 2020Review
- Expanded universal carrier screening and its implementation within a publicly funded healthcare service.Journal of community genetics · 2020Review
- Carrier screening for recessive disorders.Nature reviews. Genetics · 2019Review
- Clinical Utility of Expanded Carrier Screening: Reproductive Behaviors of At-Risk Couples.Journal of genetic counseling · 2018Article
- Prioritising the application of genomic medicine.NPJ genomic medicine · 2017Review
- Cystic fibrosis carrier screening effects on birth prevalence and newborn screening.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Shock, adjust, decide: reproductive decision making in cystic fibrosis (CF) carrier couples--a qualitative study.Journal of genetic counseling · 2011Article
- Some ethical issues in the prenatal diagnosis of sickle cell anaemia.Annals of Ibadan postgraduate medicine · 2009Article
- The relevance of sweat testing for the diagnosis of cystic fibrosis in the genomic era.The Clinical biochemist. Reviews · 2005Article
- Cystic fibrosis during pregnancy.Canadian family physician Medecin de famille canadien · 2002Review
- Reproductive decisions after neonatal screening identifies cystic fibrosis.Archives of disease in childhood. Fetal and neonatal edition · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntenatal screening for cystic fibrosis has been endorsed by the US National Institutes of Health. Edinburgh is the only city in the UK with an established routine antenatal screening programme for cystic fibrosis.
aimsTo report the change in numbers of infants diagnosed with cystic fibrosis born in Edinburgh after the introduction of antenatal screening for the disease. POPULATION: Infants diagnosed as having cystic fibrosis (by sweat test or genotyping, or both) in the seven years before antenatal testing (1984-90) and the first five years of antenatal testing (1991-95). Children born in this region who had moved before diagnosis were identified from the UK cystic fibrosis survey database.
resultsThe incidence of cystic fibrosis decreased from an average of 4.6 to 1.6 children each year with antenatal screening. The reduction in the incidence (65%) was greater than that accounted for by prenatal diagnosis and termination (36%). Of the eight children born with cystic fibrosis during the period of antenatal screening, five had been subject to antenatal screening: three had only one mutation identified, one was missed due to a laboratory error, and one was identified as a one in four risk, but prenatal diagnosis was not performed.
conclusionsAntenatal testing for cystic fibrosis has successfully reduced the incidence of cystic fibrosis in this region. Although the numbers are small, it is possible that the reduction in numbers may have been greater than might be expected from antenatal screening alone.
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