ArticleJournal of virology1998
Evolution of hypervariable region 1 of hepatitis C virus in primary infection.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 82 citations in OpenAlex.
- Prediction of suitable T and B cell epitopes for eliciting immunogenic response against SARS-CoV-2 and its mutant.Network modeling and analysis in health informatics and bioinformatics · 2022Article
- BK polyomavirus diversity-Why viral variation matters.Reviews in medical virology · 2020Review
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- Characterization of HCV genotype 5a envelope proteins: implications for vaccine development and therapeutic entry target.Hepatitis monthly · 2014Article
- Evidence of distinct populations of hepatitis C virus in the liver and plasma of patients co-infected with HIV and HCV.Journal of medical virology · 2014Article
- Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach.Drug design, development and therapy · 2014Article
- GB Virus C/Hepatitis G Virus Envelope Glycoprotein E2: Computational Molecular Features and Immunoinformatics Study.Hepatitis monthly · 2013Review
- An insight into the diagnosis and pathogenesis of hepatitis C virus infection.World journal of gastroenterology · 2013Review
- Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.Journal of virology · 2012Article
- Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.Viruses · 2010Article
- Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin.PloS one · 2008Article
- Acute hepatitis C virus infection: a chronic problem.Hepatology (Baltimore, Md.) · 2008Review
- Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome.Journal of virology · 2005Article
- Multigene tracking of quasispecies in viral persistence and clearance of hepatitis C virus.World journal of gastroenterology · 2005Article
- Wide range of quasispecies diversity during primary hepatitis C virus infection.Journal of virology · 2005Article
- High-resolution phylogenetic analysis of hepatitis C virus adaptation and its relationship to disease progression.Journal of virology · 2004Article
- Comparison of hepatitis C viral loads in patients with or without coinfection with different genotypes.Clinical and diagnostic laboratory immunology · 2004Article
- Vertical transmission of the hepatitis C virus to infants of anti-human immunodeficiency virus-negative mothers: molecular evolution of hypervariable region 1 in prenatal and perinatal or postnatal infections.Journal of clinical microbiology · 2003Article
- Managing occupational risks for hepatitis C transmission in the health care setting.Clinical microbiology reviews · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypervariable region 1 (HVR-1) of the putative envelope encoding E2 region of hepatitis C virus (HCV) RNA was analyzed in sequential samples from three patients with acute type C hepatitis infected from different sources to address (i) the dynamics of intrahost HCV variability during the primary infection and (ii) the role of host selective pressure in driving viral genetic evolution. HVR-1 sequences from 20 clones per each point in time were analyzed after amplification, cloning, and purification of plasmid DNA from single colonies of transformed cells. The intrasample evolutionary analysis (nonsynonymous mutations per nonsynonymous site [Ka], synonymous mutations per synonymous site [Ks], Ka/Ks ratio, and genetic distances [gd]) documented low gd in early samples (ranging from 2. 11 to 7.79%) and a further decrease after seroconversion (from 0 to 4.80%), suggesting that primary HCV infection is an oligoclonal event, and found different levels and dynamics of host pressure in the three cases. The intersample analysis (pairwise comparisons of intrapatient sequences; rKa, rKs, rKa/rKs ratio, and gd) confirmed the individual features of HCV genetic evolution in the three subjects and pointed to the relative contribution of either neutral evolution or selective forces in driving viral variability, documenting that adaptation of HCV for persistence in vivo follows different routes, probably representing the molecular counterpart of the viral fitness for individual environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.