ArticleJournal of virology1998
Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 137 citations in OpenAlex.
- Structural basis for nuclear import of adeno-associated virus serotype 6 capsid protein.Journal of virology · 2025Article
- The longitudinal kinetics of AAV5 vector integration profiles and evaluation of clonal expansion in mice.Molecular therapy. Methods & clinical development · 2024Article
- Routes of administration for adeno-associated viruses carrying gene therapies for brain diseases.Frontiers in molecular neuroscience · 2022Review
- Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions.Journal of hematology & oncology · 2019Review
- Review
- AAV Delivery of Endothelin-1 shRNA Attenuates Cold-Induced Hypertension.Human gene therapy · 2017Review
- Interaction between Nef and INI1/SMARCB1 augments replicability of HIV-1 in resting human peripheral blood mononuclear cells.Archives of virology · 2015Article
- Systemic AAVrh10 provides higher transgene expression than AAV9 in the brain and the spinal cord of neonatal mice.Frontiers in molecular neuroscience · 2015Article
- Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis.Biochimica et biophysica acta · 2013Review
- A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting.British journal of clinical pharmacology · 2013Review
- Intracisternal rSV40 administration provides effective pan-CNS transgene expression.Gene therapy · 2012Article
- Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe.Gene therapy · 2011Article
- Gene transfer to the cerebellum.Cerebellum (London, England) · 2010Article
- Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Adeno-associated virus vector integration.Current opinion in molecular therapeutics · 2009Review
- Adeno-associated virus-2 and its primary cellular receptor--Cryo-EM structure of a heparin complex.Virology · 2009Article
- Methods, potentials, and limitations of gene delivery to regenerate central nervous system cells.Biologics : targets & therapy · 2009Article
- Integration of reporter transgenes into Schistosoma mansoni chromosomes mediated by pseudotyped murine leukemia virus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectors.Gene therapy · 2007Article
- AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage.Gene therapy · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The site-specific integration of wild-type adeno-associated virus (wtAAV) into the human genome is a very attractive feature for the development of AAV-based gene therapy vectors. However, knowledge about integration of wtAAV, as well as currently configured recombinant AAV (rAAV) vectors, is limited. By using a modified Alu-PCR technique to amplify and sequence the vector-cellular junctions, we provide the first direct evidence both in vitro and in vivo of rAAV-mediated transgene integration in several types of nondividing cells, including neurons. This novel technique will be highly useful for further delineating the mechanisms underlying AAV-mediated integration, including issues of frequency, site preference, and DNA rearrangement in human as well as animal cells. Results from these studies should be beneficial for the development of the next generation of gene delivery vectors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.