ArticleJournal of virology1998
Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Severe murine schistosomiasis results from disrupted CD4+ T-cell modulation by immunodominance of a single egg epitope.Einstein (Sao Paulo, Brazil) · 2024Article
- Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.Human molecular genetics · 2013Article
- Pathogenesis of murine coronavirus in the central nervous system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Pathogenic potential of borna disease virus lacking the immunodominant CD8 T-cell epitope.Journal of virology · 2007Article
- Transplantation of glial-committed progenitor cells into a viral model of multiple sclerosis induces remyelination in the absence of an attenuated inflammatory response.Experimental neurology · 2006Article
- Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence.Journal of virology · 2005Article
- How the SARS vaccine effort can learn from HIV-speeding towards the future, learning from the past.Vaccine · 2003Review
- Article
- Selection of and evasion from cytotoxic T cell responses in the central nervous system.Advances in virus research · 2001Review
- A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination.Journal of virology · 2000Article
- Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus.Journal of virology · 1999Article
- A review of coronavirus infection in the central nervous system of cats and mice.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
C57BL/6 mice infected with mouse hepatitis virus strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis several weeks after inoculation. Previously, we showed that mutations in the immunodominant CD8 T-cell epitope (S-510-518) could be detected in nearly all samples of RNA and virus isolated from these mice. These mutations abrogated recognition by T cells harvested from the central nervous systems of infected mice in direct ex vivo cytotoxicity assays. These results suggested that cytotoxic T-lymphocyte (CTL) escape mutants contributed to virus amplification and the development of clinical disease in mice infected with wild-type virus. In the present study, the importance of these mutations was further evaluated by infecting naive mice with MHV-JHM variants isolated from infected mice and in which epitope S-510-518 was mutated. Compared to mice infected with wild-type virus, variant virus-infected animals showed higher mortality and morbidity manifested by decreased weight gain and neurological signs. Although a delay in the kinetics of virus clearance has been demonstrated in previous studies of CTL escape mutants, this is the first illustration of significant changes in clinical disease resulting from infection with viruses able to evade the CD8 T-cell immune response.
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Registered trials
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