ArticleJournal of virology1998
Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Neutralization Synergy between HIV-1 Attachment Inhibitor Fostemsavir and Anti-CD4 Binding Site Broadly Neutralizing Antibodies against HIV.Journal of virology · 2019Article
- High-level production of replication-defective human immunodeficiency type 1 virus vector particles using helper-dependent adenovirus vectors.Molecular therapy. Methods & clinical development · 2015Article
- Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.Journal of virology · 2012Article
- Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd.PloS one · 2012Article
- CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21.The Journal of clinical investigation · 2011Article
- The effect of lentivirus-mediated TH and GDNF genetic engineering mesenchymal stem cells on Parkinson's disease rat model.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Article
- Quantitative fluorescence resonance energy transfer microscopy analysis of the human immunodeficiency virus type 1 Gag-Gag interaction: relative contributions of the CA and NC domains and membrane binding.Journal of virology · 2009Article
- DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice.The Journal of clinical investigation · 2009Article
- Notch signaling contributes to the pathogenesis of human osteosarcomas.Human molecular genetics · 2009Article
- Article
- Dimorphic effects of Notch signaling in bone homeostasis.Nature medicine · 2008Article
- Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release.Virology · 2007Article
- Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1.Journal of virology · 2006Article
- HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1.The journal of gene medicine · 2006Article
- Expression of glucose transporter 1 confers susceptibility to human T-cell leukemia virus envelope-mediated fusion.Journal of virology · 2005Article
- Lentivirus-mediated gene transfer to the respiratory epithelium: a promising approach to gene therapy of cystic fibrosis.Gene therapy · 2004Review
- Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages.Journal of virology · 2004Article
- Identification of synthetic endothelial cell-specific promoters by use of a high-throughput screen.Journal of virology · 2004Article
- EBNA2 amino acids 3 to 30 are required for induction of LMP-1 and immortalization maintenance.Journal of virology · 2004Article
- Jaagsiekte sheep retrovirus envelope efficiently pseudotypes human immunodeficiency virus type 1-based lentiviral vectors.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Lentiviruses are potentially advantageous compared to oncoretroviruses as gene transfer agents because they can infect nondividing cells. We demonstrate here that human immunodeficiency virus type 1 (HIV-1)-based vectors were highly efficient in transducing purified human hematopoietic stem cells. Transduction rates, measured by marker gene expression or by PCR of the integrated provirus, exceeded 50%, and transduction appeared to be independent of mitosis. Derivatives of HIV-1 were constructed to optimize the vector, and a deletion of most of Vif and Vpr was required to ensure the long-term persistence of transduced cells with relatively stable expression of the marker gene product. These results extend the utility of this lentivirus vector system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.