ArticleThe Biochemical journal1998
Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 214 citations in OpenAlex.
- Nitric oxide synthase inhibition with L-NAME reduces maximal oxygen uptake but not gas exchange threshold during incremental cycle exercise in man.The Journal of physiology · 2004Trial
- Nitric Oxide Does Not Improve Liver Mitochondrial Function 48 Hours After Cecal Ligation and Perforation in Experimental Sepsis.Antioxidants (Basel, Switzerland) · 2025Article
- Calcium-Dependent Interaction of Nitric Oxide Synthase with CytochromeBrain sciences · 2023Article
- Deficits in Prenatal Serine Biosynthesis Underlie the Mitochondrial Dysfunction Associated with the Autism-LinkedInternational journal of molecular sciences · 2021Article
- The Role of Nitric Oxide in Cancer: Master Regulator or NOt?International journal of molecular sciences · 2020Review
- Endogenous nitric oxide formation in cardiac myocytes does not control respiration during β-adrenergic stimulation.The Journal of physiology · 2017Article
- The Role of Antioxidant Enzymes in the Ovaries.Oxidative medicine and cellular longevity · 2017Review
- NO-sGC Pathway Modulates CaFrontiers in physiology · 2017Article
- Select nutrients and their effects on conceptus development in mammals.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2015Review
- Nitric oxide mediates strigolactone signaling in auxin and ethylene-sensitive lateral root formation in sunflower seedlings.Plant signaling & behavior · 2015Article
- Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling.Antioxidants & redox signaling · 2014Review
- Endogenous NO upon estradiol-17β stimulation and NO donor differentially regulate mitochondrial S-nitrosylation in endothelial cells.Endocrinology · 2014Article
- Neuronal injury from cardiac arrest: aging years in minutes.Age (Dordrecht, Netherlands) · 2014Review
- Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats.PloS one · 2013Article
- Regulation of mitochondrial processes by protein S-nitrosylation.Biochimica et biophysica acta · 2012Review
- Correlation between total nitrite/nitrate concentrations and monoamine oxidase (types A and B) and semicarbazide-sensitive amine oxidase enzymatic activities in human mesenteric arteries from non-diabetic and type 2 diabetic patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Measuring mitochondrial function in intact cardiac myocytes.Journal of molecular and cellular cardiology · 2012Review
- The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species.Journal of bioenergetics and biomembranes · 2011Review
- Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity.Journal of bioenergetics and biomembranes · 2010Article
- Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging.American journal of physiology. Endocrinology and metabolism · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The effects of endogenous production of NO., catalysed by the mitochondrial nitric oxide synthase (NOS), on mitochondrial metabolism were studied. The respiratory rates of intact mitochondria in State 4 were decreased by 40% and 28% with succinate and malate-glutamate, respectively, in the presence of L-arginine (L-Arg); conversely, the O2 uptake with NG-methyl-L-arginine (NMMA), a competitive inhibitor of NOS, was increased. The production of NO. and the inhibition of the respiratory rates were dependent on the metabolic state in which mitochondria were maintained: NO. production was probably supported by mitochondrial NADPH, the latter maintained by the energy-dependent transhydrogenase. In addition to the decline in the respiratory rate, an inhibition of ATP synthesis was also observed (40-50%) following supplementation with L-Arg. The dependence of the respiratory rates of mitochondria in State 3 and cytochrome oxidase activities on O2 concentrations with either L-Arg or NMMA indicated that both processes were competitively inhibited by NO. at the cytochrome oxidase level. This inhibition can be explained by the interaction of NO. with cytochrome oxidase at the binuclear centre. The role of NO. as a physiological modulator of cytochrome oxidase is discussed in terms of cellular metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.