ArticleThe Biochemical journal1998
Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy.Scientific reports · 2021Article
- Article
- Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.Journal of medicinal chemistry · 2012Article
- Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Apoptosis in Schwann cell cultures is closely interrelated with the activity of the ubiquitin-proteasome proteolytic pathway.Neurochemical research · 2002Article
- The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro--from cytotoxic synergy to complete inhibition of apoptosis.British journal of pharmacology · 2002Article
- The proteasome: a novel target for cancer chemotherapy.Leukemia · 2002Review
- Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation.British journal of pharmacology · 2001Article
- Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.The Biochemical journal · 2001Article
- Polyamines directly induce release of cytochrome c from heart mitochondria.The Biochemical journal · 2000Article
- Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis.The Biochemical journal · 1999Article
- Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin.The Journal of clinical investigation · 1999Article
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Authors and funding
8 authors.
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Abstract
Recent investigations have indicated the involvement of proteasome in programmed cell death. The present studies show that although peptide aldehyde inhibitors of proteasome are by themselves weak inducers of apoptosis, they inhibit the apoptotic effect of the anticancer drug etoposide in rat thymocytes. Acetyl-Leu-Leu-norvalinal (LLnV-al) and other related peptide aldehydes inhibited the increase in caspase activity and DNA fragmentation that followed treatment with etoposide and their effect was related to their potency as proteasome inhibitors. To inhibit etoposide-induced apoptosis, LLnV-al must be present within 3 h of treatment with etoposide, in the same way as the inhibitor of protein synthesis cycloheximide must be. Etoposide caused a rapid accumulation of p53 protein that was not inhibited by LLnV-al, which was also a strong inducer of p53. Peptide aldehydes were also weak activators of caspase activity, suggesting that the same mechanism, i.e. the blocking of proteasome function, both triggers apoptosis and inhibits the effect of etoposide. These results are consistent with a model in which proteasome is selectively involved in the pathway used by etoposide to induce cell suicide.
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