ArticleGenes & development1998
A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Independent Evolution of the MYB Family in Brown Algae.Frontiers in genetics · 2021Article
- Article
- Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.Science (New York, N.Y.) · 2014Article
- The carboxy-terminal domain of Dictyostelium C-module-binding factor is an independent gene regulatory entity.PloS one · 2009Article
- The C-module DNA-binding factor mediates expression of the dictyostelium aggregation-specific adenylyl cyclase ACA.Eukaryotic cell · 2006Article
- CbfA, the C-module DNA-binding factor, plays an essential role in the initiation of Dictyostelium discoideum development.Eukaryotic cell · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dictyostelium development is induced by starvation. The adenylyl cyclase gene ACA is one of the first genes expressed upon starvation. ACA produces extracellular cAMP that induces chemotaxis, aggregation, and differentiation in neighboring cells. Using insertional mutagenesis we have isolated a mutant that does not aggregate upon starvation but is rescued by adding extracellular cAMP. Sequencing of the mutated locus revealed a new gene, DdMYB2, whose product contains three Myb repeats, the DNA-binding motif of Myb-related transcription factors. Ddmyb2-null cells show undetectable levels of ACA transcript and no cAMP production. Ectopic expression of ACA from a constitutive promotor rescues differentiation and morphogenesis of Ddmyb2-null mutants. The results suggest that development in Dictyostelium starts by starvation-mediated DdMyb2 activation, which induces adenylyl cyclase activity producing the differentiation-inducing signal cAMP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.