ArticleGenes & development1998
Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switching.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Transcriptome profiling of transcription factors inFrontiers in microbiology · 2022Article
- A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure.PLoS genetics · 2019Article
- Homology Requirements and Competition between Gene Conversion and Break-Induced Replication during Double-Strand Break Repair.Molecular cell · 2017Article
- Chromosome-refolding model of mating-type switching in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Conformation of Yeast Chromosome III Is Mating Type Dependent and Controlled by the Recombination Enhancer.Cell reports · 2015Article
- Review
- Regulation of budding yeast mating-type switching donor preference by the FHA domain of Fkh1.PLoS genetics · 2012Article
- Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Dynamics of homology searching during gene conversion in Saccharomyces cerevisiae revealed by donor competition.Genetics · 2011Article
- The evolution of sex: a perspective from the fungal kingdom.Microbiology and molecular biology reviews : MMBR · 2010Review
- Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex.Molecular and cellular biology · 2009Article
- Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome.PLoS genetics · 2006Article
- Cell cycle-dependent regulation of Saccharomyces cerevisiae donor preference during mating-type switching by SBF (Swi4/Swi6) and Fkh1.Molecular and cellular biology · 2006Article
- Saccharomyces cerevisiae donor preference during mating-type switching is dependent on chromosome architecture and organization.Genetics · 2006Article
- Roles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae.Current genetics · 2005Article
- The DNA repair protein yKu80 regulates the function of recombination enhancer during yeast mating type switching.Molecular and cellular biology · 2005Article
- Yeast recombination enhancer is stimulated by transcription activation.Molecular and cellular biology · 2005Article
- Global chromatin structure of 45,000 base pairs of chromosome III in a- and alpha-cell yeast and during mating-type switching.Molecular and cellular biology · 2004Article
- Mcm1 promotes replication initiation by binding specific elements at replication origins.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Switching of Saccharomyces mating type by replacement of sequences at the MAT locus involves a choice between two donors, HML and HMR. MATalpha cells inhibit recombination along the entire left arm of chromosome III, including HML, whereas MATa cells activate this same region. MATa-dependent activation of HML depends on a small, cis-acting DNA sequence designated the recombination enhancer (RE), located 17 kb centromere-proximal to HML. A comparison of RE sequences interchangeable between Saccharomyces cerevisiae and Saccharomyces carlsbergensis defines a minimum RE of 244 bp. RE activity is repressed in MATalpha cells by binding of the Matalpha2-Mcm1 corepressor to a site within the RE. Mutation of the two Matalpha2 binding sites removes most, but not all, of this repression, and RE chromatin structure in MATalpha cells becomes indistinguishable from that seen in MATa. Surprisingly, a 2-bp mutation in the Mcm1 binding site completely abolishes RE activity in MATa cells; moreover, RE chromatin structure in the MATa mutant becomes very similar to that seen in MATalpha cells with a normal RE, displaying highly ordered nucleosomes despite the absence of Matalpha2. Further, a mutation that alters the ability of Mcm1 to act with Matalpha2 in repressing a-specific genes also alters donor preference in either mating type. Thus, Mcm1 is critically responsible for the activation as well as the Matalpha2-Mcm1-mediated repression of RE activity.
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