ArticleGenes & development1998
Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 145 citations in OpenAlex.
- The LOTUS domain of Oskar promotes localisation of both protein and mRNA components ofbioRxiv : the preprint server for biology · 2025Article
- Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.Molecular & cellular proteomics : MCP · 2020Article
- An Interaction Network of RNA-Binding Proteins Involved inMolecular & cellular proteomics : MCP · 2020Article
- Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters.Molecular cell · 2020Article
- Review
- Translational Control of Germ Cell Decisions.Results and problems in cell differentiation · 2017Review
- Translational activation of oskar mRNA: reevaluation of the role and importance of a 5' regulatory element [corrected].PloS one · 2015Article
- Primordial Germ Cell Specification and Migration.F1000Research · 2015Review
- Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.PLoS genetics · 2015Article
- Emerging roles for hnRNPs in post-transcriptional regulation: what can we learn from flies?Chromosoma · 2014Review
- Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.Molecular and cellular biology · 2013Article
- Molecular insights into intracellular RNA localization.International review of cell and molecular biology · 2013Review
- Translational control in oocyte development.Cold Spring Harbor perspectives in biology · 2011Review
- Sm proteins specify germ cell fate by facilitating oskar mRNA localization.Development (Cambridge, England) · 2010Article
- BREs mediate both repression and activation of oskar mRNA translation and act in trans.Developmental cell · 2010Article
- In vivo colocalisation of oskar mRNA and trans-acting proteins revealed by quantitative imaging of the Drosophila oocyte.PloS one · 2009Article
- Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Genes & development · 2009Article
- Temporal and spatial control of germ-plasm RNAs.Current biology : CB · 2009Article
- Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells.Development (Cambridge, England) · 2008Article
- A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precise restriction of proteins to specific domains within a cell plays an important role in early development and differentiation. An efficient way to localize and concentrate proteins is by localization of mRNA in a translationally repressed state, followed by activation of translation when the mRNA reaches its destination. A central issue is how localized mRNAs are derepressed. In this study we demonstrate that, when oskar mRNA reaches the posterior pole of the Drosophila oocyte, its translation is derepressed by an active process that requires a specific element in the 5' region of the mRNA. We demonstrate that this novel type of element is a translational derepressor element, whose functional interaction with the previously identified repressor region in the oskar 3' UTR is required for activation of oskar mRNA translation at the posterior pole. The derepressor element only functions at the posterior pole, suggesting that a locally restricted interaction between trans-acting factors and the derepressor element may be the link between mRNA localization and translational activation. We also show specific interaction of two proteins with the oskar mRNA 5' region; one of these also recognizes the 3' repressor element. We discuss the possible involvement of these factors as well as known genes in the process of localization-dependent translation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.