ArticleJournal of clinical microbiology1998
Antigenic and genomic diversity of human rotavirus VP4 in two consecutive epidemic seasons in Mexico.
Article in Journal of clinical microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Group A rotaviruses in children with gastroenteritis in a Canadian pediatric hospital: The prevaccine era.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2013Article
- Prevalence and genetic diversity of human astroviruses in Mexican children with symptomatic and asymptomatic infections.Journal of clinical microbiology · 2004Article
- Rotavirus diarrhea severity is related to the VP4 type in Mexican children.Journal of clinical microbiology · 2003Article
- Rotavirus strain diversity in Blantyre, Malawi, from 1997 to 1999.Journal of clinical microbiology · 2001Article
- VP4 and VP7 genotyping by reverse transcription-PCR of human rotavirus in mexican children with acute diarrhea.Journal of clinical microbiology · 2000Article
- Genotype profiles of rotavirus strains from children in a suburban community in Guinea-Bissau, Western Africa.Journal of clinical microbiology · 2000Article
- Comparison of enzyme immunoassay and reverse transcriptase PCR for identification of serotype G9 rotaviruses.Journal of clinical microbiology · 1999Article
- Evidence of high-frequency genomic reassortment of group A rotavirus strains in Bangladesh: emergence of type G9 in 1995.Journal of clinical microbiology · 1999Article
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Authors and funding
17 authors.
Funding
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Abstract
In the present investigation we characterized the antigenic diversity of the VP4 and VP7 proteins in 309 and 261 human rotavirus strains isolated during two consecutive epidemic seasons, respectively, in three different regions of Mexico. G3 was found to be the prevalent VP7 serotype during the first year, being superseded by serotype G1 strains during the second season. To antigenically characterize the VP4 protein of the strains isolated, we used five neutralizing monoclonal antibodies (MAbs) which showed specificity for VP4 serotypes P1A, P1B, and P2 in earlier studies. Eight different patterns of reactivity with these MAbs were found, and the prevalence of three of these patterns varied from one season to the next. The P genotype of a subset of 52 samples was determined by PCR. Among the strains characterized as genotype P[4] and P[8] there were three and five different VP4 MAb reactivity patterns, respectively, indicating that the diversity of neutralization epitopes in VP4 is greater than that previously appreciated by the genomic typing methods.
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