ArticleJournal of clinical microbiology1998
Tubulointerstitial nephritis due to a mutant polyomavirus BK virus strain, BKV(Cin), causing end-stage renal disease.
Article in Journal of clinical microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Native kidney BK virus nephropathy, a systematic review.Transplant infectious disease : an official journal of the Transplantation Society · 2019Pooled it
- Investigation of simian virus 40 (SV40) and human JC, BK, MC, KI, and WU polyomaviruses in glioma.Journal of neurovirology · 2020Article
- BK Polyomavirus Virus Glomerular Tropism: Implications for Virus Reactivation from Latency and Amplification during Immunosuppression.Journal of clinical medicine · 2019Review
- BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection.World journal of transplantation · 2016Review
- Molecular characterization of BK virus in patients infected with human immunodeficiency virus.Medical microbiology and immunology · 2016Article
- Phylogenetic reconstruction and polymorphism analysis of BK virus VP2 gene isolated from renal transplant recipients in China.Experimental and therapeutic medicine · 2015Article
- A system for the analysis of BKV non-coding control regions: application to clinical isolates from an HIV/AIDS patient.Virology · 2010Article
- Hemorrhagic cystitis and possible neurologic disease from BK virus infection in a patient with AIDS.Infection · 2010Article
- Genotyping schemes for polyomavirus BK, using gene-specific phylogenetic trees and single nucleotide polymorphism analysis.Journal of virology · 2009Article
- Viruses and kidney disease: beyond HIV.Seminars in nephrology · 2008Review
- Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology.The Journal of experimental medicine · 2008Article
- Direct correlation between sialic acid binding and infection of cells by two human polyomaviruses (JC virus and BK virus).Journal of virology · 2008Article
- Detection and typing of BKV, JCV, and SV40 by multiplex nested polymerase chain reaction.Molecular biotechnology · 2007Article
- An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus.Journal of virology · 2005Article
- BKV-DNA and JCV-DNA co-quantification assay to evaluate viral load in urine and serum.Molecular biotechnology · 2005Article
- High reactivation of BK virus variants in Asian Indians with renal disorders and during pregnancy.Virus genes · 2004Article
- Cynomolgus polyoma virus infection: a new member of the polyoma virus family causes interstitial nephritis, ureteritis, and enteritis in immunosuppressed cynomolgus monkeys.The American journal of pathology · 1999Article
- Is SV40 a tumorigenic human pathogen?Brain pathology (Zurich, Switzerland) · 1999Article
- AIDS-Associated BK Virus Nephropathy in Native Kidneys: A Case Report and Review of the Literature.Journal of investigative medicine high impact case reportsReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A renal biopsy from a 36-year-old man with AIDS showed a severe tubulointerstitial nephritis with intranuclear inclusions in epithelial cells. Electron microscopy revealed the characteristic findings of a polyomavirus (PyV) infection, and immunofluorescence indicated the presence of BK virus (BKV) antigen. Inoculation of rhesus monkey kidney cell cultures both with urine and with buffy coat blood cells resulted in a cytopathic response which was subsequently confirmed to be due to BKV. Further characterization of the viral DNA from the kidney by PCR amplification and Southern blot analysis with PyV and strain-specific primers and probes indicated that the virus was closely related to the BK(Dun) strain but different in its apparent sequence arrangement. Subsequent cycle sequencing showed a dinucleotide mutation of TG-->AA which substitutes hydrophilic Gln for hydrophobic Leu in a sequence homologous to an origin DNA-binding domain of simian virus 40 T antigen. It is suggested that the mutation and a coding region rearrangement of this strain of BKV designated BKV(Cin) has the potential to alter viral DNA replication and enhance pathogenicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.