ArticleProceedings of the National Academy of Sciences of the United States of America1998
Modulation of an early step in the secretory machinery in hippocampal nerve terminals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
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- Neuromuscular recovery from botulism involves multiple forms of compensatory plasticity.Frontiers in cellular neuroscience · 2023Article
- Caffeine accelerates recovery from general anesthesia via multiple pathways.Journal of neurophysiology · 2017Article
- Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.Molecular brain · 2015Article
- Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons.Journal of neurophysiology · 2014Article
- Caffeine accelerates recovery from general anesthesia.Journal of neurophysiology · 2014Article
- Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Activation of group II metabotropic glutamate receptors inhibits glutamatergic transmission in the rat entorhinal cortex via reduction of glutamate release probability.Cerebral cortex (New York, N.Y. : 1991) · 2012Article
- Intrinsic variability in Pv, RRP size, Ca(2+) channel repertoire, and presynaptic potentiation in individual synaptic boutons.Frontiers in synaptic neuroscience · 2012Article
- Esmolol modulates inhibitory neurotransmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat.BMC anesthesiology · 2011Article
- Opposing functions of two sub-domains of the SNARE-complex in neurotransmission.The EMBO journal · 2010Article
- Cyclic AMP potentiates Ca2+-dependent exocytosis in pancreatic duct epithelial cells.The Journal of general physiology · 2010Article
- The role of the t-SNARE SNAP-25 in action potential-dependent calcium signaling and expression in GABAergic and glutamatergic neurons.BMC neuroscience · 2008Article
- Differential abilities of SNAP-25 homologs to support neuronal function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Action of botulinum neurotoxins in the central nervous system: antiepileptic effects.Neurotoxicity research · 2006Review
- Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles.The EMBO journal · 2006Article
- Modulation of calcium currents is eliminated after cleavage of a strategic component of the mammalian secretory apparatus.The Journal of physiology · 2005Article
- cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity.Pharmacology & therapeutics · 2005Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
In hippocampal neurons, neurotransmitter release can be regulated by protein kinase A (PKA) through a direct action on the secretory machinery. To identify the site of PKA modulation, we have taken advantage of the ability of the neurotoxin Botulinum A to cleave the synaptic protein SNAP-25. Cleavage of this protein decreases the Ca2+ responsiveness of the secretory machinery by partially uncoupling Ca2+-sensing from fusion per se. This is expressed as a shift toward higher Ca2+ levels of the Ca2+ to neurotransmitter release relationship and as a perturbation of synaptic delay under conditions where secretion induced by the Ca2+-independent secretagogue ruthenium red is unimpaired. We find that SNAP-25 cleavage also perturbs PKA-dependent modulation of secretion; facilitation of ruthenium red-evoked neurotransmitter release by the adenylyl cyclase activator forskolin is blocked completely after Botulinum toxin A action. Together with our observation that forskolin modifies the Ca2+ to neurotransmitter release relationship, our results suggest that SNAP-25 acts as a functional linker between Ca2+ detection and fusion and that PKA modulates an early step in the secretory machinery related to calcium sensing to facilitate synaptic transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.