ArticleProceedings of the National Academy of Sciences of the United States of America1998
The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Breast Cancer: Mitochondria-Centered Metabolic Alterations in Tumor and Associated Adipose Tissue.Cells · 2024Article
- Lipid metabolism dynamics in cancer stem cells: potential targets for cancers.Frontiers in pharmacology · 2024Review
- Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells.Theranostics · 2020Review
- The serum level of a novel lipogenic protein Spot 14 was reduced in metabolic syndrome.PloS one · 2019Article
- When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance.Cancer communications (London, England) · 2018Review
- Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin.Oncotarget · 2016Article
- Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered.Journal of cellular physiology · 2016Review
- Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?The Journal of investigative dermatology · 2016Article
- Obesity and cancer progression: is there a role of fatty acid metabolism?BioMed research international · 2015Review
- Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.Breast cancer research : BCR · 2014Article
- Metabolic circuits in neural stem cells.Cellular and molecular life sciences : CMLS · 2014Review
- Transcriptional analysis of abdominal fat in genetically fat and lean chickens reveals adipokines, lipogenic genes and a link between hemostasis and leanness.BMC genomics · 2013Article
- Chemical genetics of acetyl-CoA carboxylases.Molecules (Basel, Switzerland) · 2013Review
- Article
- Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis.Endocrinology · 2010Article
- The role of sex steroid receptors on lipogenesis in breast and prostate carcinogenesis: a viewpoint.Hormones & cancer · 2010Review
- Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells.Nutrition and cancer · 2009Article
- Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate.Endocrinology · 2008Article
- Monoallelic expression of multiple genes in the CNS.PloS one · 2007Article
- The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells.The Biochemical journal · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Enhanced long chain fatty acid synthesis may occur in breast cancer, where it is necessary for tumor growth and predicts a poor prognosis. "Spot 14" (S14) is a carbohydrate- and thyroid hormone-inducible nuclear protein specific to liver, adipose, and lactating mammary tissues that functions to activate genes encoding the enzymes of fatty acid synthesis. Amplification of chromosome region 11q13, where the S14 gene (THRSP) resides, also predicts a poor prognosis in breast tumors. We localized the S14 gene between markers D11S906 and D11S937, at the telomeric end of the amplified region at 11q13, and found that it was amplified and expressed in breast cancer-derived cell lines. Moreover, concordant expression of S14 and a key lipogenic enzyme (acetyl-CoA carboxylase) in a panel of primary breast cancer specimens strongly supported a role for S14 as a determinant of tumor lipid metabolism. S14 expression provides a pathophysiological link between two prognostic indicators in breast cancer: enhanced lipogenesis and 11q13 amplification.
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