ArticleProceedings of the National Academy of Sciences of the United States of America1998
Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed.
- Cancer-testis antigen 7 expression and immune responses following allogeneic stem cell transplantation for multiple myeloma.Cancer immunology research · 2014Trial
- An immune-active tumor microenvironment favors clinical response to ipilimumab.Cancer immunology, immunotherapy : CII · 2012Trial
- A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L.Journal of immunology (Baltimore, Md. : 1950) · 2004Trial
- Immune Evasion in Ovarian Cancer Peritoneal Metastasis: Mechanisms and Biomarker-Guided Therapeutic Matching.Journal of cellular physiology · 2026Review
- Melanoma-associated antigen A4: A cancer/testis antigen as a target for adoptive T-cell receptor T-cell therapy.Cancer treatment reviews · 2025Review
- Emerging targeted and cellular therapies in the treatment of advanced and metastatic synovial sarcoma.Frontiers in oncology · 2023Review
- Targeting cancer testis antigens in synovial sarcoma.Journal for immunotherapy of cancer · 2021Review
- UpregulatingJournal of Cancer · 2021Article
- The ectopic expression of meiCT genes promotes meiomitosis and may facilitate carcinogenesis.Cell cycle (Georgetown, Tex.) · 2020Review
- Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients.Journal for immunotherapy of cancer · 2019Article
- Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis.BioImpacts : BI · 2019Article
- Identification of tumor antigens in malignant mesothelioma.Oncology letters · 2017Article
- Unmasking targets of antitumor immunity via high-throughput antigen profiling.Current opinion in biotechnology · 2016Review
- Tumor-infiltrating lymphocytes for the treatment of metastatic cancer.Molecular oncology · 2015Review
- H1N1 viral proteome peptide microarray predicts individuals at risk for H1N1 infection and segregates infection versus Pandemrix(®) vaccination.Immunology · 2015Article
- Review
- Seminal plasma as a diagnostic fluid for male reproductive system disorders.Nature reviews. Urology · 2014Review
- Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy.Nature reviews. Cancer · 2014Review
- Expression and immune responses to MAGE antigens predict survival in epithelial ovarian cancer.PloS one · 2014Article
- A novel approach to biomarker discovery in head and neck cancer using an autoantibody signature.Oncogene · 2013Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer/testis (CT) antigens-immunogenic protein antigens that are expressed in testis and a proportion of diverse human cancer types-are promising targets for cancer vaccines. To identify new CT antigens, we constructed an expression cDNA library from a melanoma cell line that expresses a wide range of CT antigens and screened the library with an allogeneic melanoma patient serum known to contain antibodies against two CT antigens, MAGE-1 and NY-ESO-1. cDNA clones isolated from this library identified four CT antigen genes: MAGE-4a, NY-ESO-1, LAGE-1, and CT7. Of these four, only MAGE-4a and NY-ESO-1 proteins had been shown to be immunogenic. LAGE-1 is a member of the NY-ESO-1 gene family, and CT7 is a newly defined gene with partial sequence homology to the MAGE family at its carboxyl terminus. The predicted CT7 protein, however, contains a distinct repetitive sequence at the 5' end and is much larger than MAGE proteins. Our findings document the immunogenicity of LAGE-1 and CT7 and emphasize the power of serological analysis of cDNA expression libraries in identifying new human tumor antigens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.