ArticleProceedings of the National Academy of Sciences of the United States of America1998
Amyrel, a paralogous gene of the amylase gene family in Drosophila melanogaster and the Sophophora subgenus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster.npj aging · 2026Article
- Article
- New insights into the origin and evolution of α-amylase genes in green plants.Scientific reports · 2019Article
- α-Amylase Mediates Host Acceptance in the Braconid Parasitoid Cotesia flavipes.Journal of chemical ecology · 2018Article
- The Amylases of Insects.International journal of insect science · 2018Review
- α-Amylase: an enzyme specificity found in various families of glycoside hydrolases.Cellular and molecular life sciences : CMLS · 2014Review
- Evolutionary history of eukaryotic α-glucosidases from the α-amylase family.Journal of molecular evolution · 2013Article
- The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Characterization of maltase clusters in the genus Drosophila.Journal of molecular evolution · 2011Article
- Highly variable polymorphism of the alpha-amylase gene family in Litopenaeus vannamei (Crustacea Decapoda).Journal of molecular evolution · 2003Article
- A nested alpha-amylase gene in Drosophila ananassae.Journal of molecular evolution · 2003Article
- The population genetics of the origin and divergence of the Drosophila simulans complex species.Genetics · 2000Article
- Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We describe a gene from Drosophila melanogaster related to the alpha-amylase gene Amy. This gene, which exists as a single copy, was named Amyrel. It is strikingly divergent from Amy because the amino acid divergence is 40%. The coding sequence is interrupted by a short intron at position 655, which is unusual in amylase genes. Amyrel has also been cloned in Drosophila ananassae, Drosophila pseudoobscura, and Drosophila subobscura and is likely to be present throughout the Sophophora subgenus, but, to our knowledge, it has not been detected outside. Unexpectedly, there is a strong conservation of 5' and 3' flanking regions between Amyrel genes from different species, which is not the case for Amy and which suggests that selection acts on these regions. In contrast to the Amy genes, Amyrel is transcribed in larvae of D. melanogaster but not in adults. However, the protein has not been detected yet. Amyrel evolves about twice as fast as Amy in the several species studied. We suggest that this gene could result from a duplication of Amy followed by accelerated and selected divergence toward a new adaptation.
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