ArticleProceedings of the National Academy of Sciences of the United States of America1998
The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Expression and Function of Toll Pathway Components in the Early Development of the WaspJournal of developmental biology · 2022Article
- Isolation of secreted proteins from Drosophila ovaries and embryos through in vivo BirA-mediated biotinylation.PloS one · 2019Article
- A Developmental Program Truncates Long Transcripts to Temporally Regulate Cell Signaling.Developmental cell · 2018Article
- A ventrally localized protease in the Drosophila egg controls embryo dorsoventral polarity.Current biology : CB · 2012Article
- Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.FEBS letters · 2010Article
- Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe.Development (Cambridge, England) · 2009Article
- Sulfation of eggshell components by Pipe defines dorsal-ventral polarity in the Drosophila embryo.Current biology : CB · 2009Article
- Purification and characterization of serine proteases that exhibit caspase-like activity and are associated with programmed cell death in Avena sativa.The Plant cell · 2004Article
- Article
- Gastrulation defective, a complement factor C2/B-like protease, interprets a ventral prepattern in Drosophila.EMBO reports · 2001Article
- Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate.The EMBO journal · 2001Article
- Activation of a protease cascade involved in patterning the Drosophila embryo.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Gastrulation defective is a serine protease involved in activating the receptor toll to polarize the Drosophila embryo.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Comparative genomics of the eukaryotes.Science (New York, N.Y.) · 2000Article
- Review
- Ovochymase, a Xenopus laevis egg extracellular protease, is translated as part of an unusual polyprotease.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Maternal control of the Drosophila dorsal-ventral body axis.Wiley interdisciplinary reviews. Developmental biologyReview
- No requirement for localized Nudel protein expression in Drosophila embryonic axis determination.FlyArticle
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Authors and funding
4 authors.
Funding
Abstract
The establishment of dorsal-ventral polarity in the oocyte involves two sets of genes. One set belongs to the gurken-torpedo signaling pathway and affects the development of the egg chorion as well as the polarity of the embryo. The second set of genes affects only the dorsal-ventral polarity of the embryo but not the eggshell. gastrulation defective is one of the earliest acting of this second set of maternally required genes. We have cloned and characterized the gastrulation defective gene and determined that it encodes a protein structurally related to the serine protease superfamily, which also includes the Snake, Easter, and Nudel proteins. These data provide additional support for the involvement of a protease cascade in generating an asymmetric signal (i.e., asymmetric Spätzle activity) during establishment of dorsal-ventral polarity in the Drosophila embryo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.