ArticleThe American journal of pathology1976
Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni.
Article in The American journal of pathology, 1976. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 91 citations in OpenAlex.
- Getting into host's skin: initial immune response toFrontiers in immunology · 2025Review
- Cercarial dermatitis: a systematic follow-up study of human cases with implications for diagnostics.Parasitology research · 2018Article
- Host Defense Versus Immunosuppression: Unisexual Infection With Male or FemaleFrontiers in immunology · 2018Article
- Editorial: The Schistosomiasis Vaccine - It is Time to Stand up.Frontiers in immunology · 2015Article
- Cloning and characterization of a calcium-binding, histamine-releasing protein from Schistosoma mansoni.The Journal of biological chemistry · 2002Article
- Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Immunopathology of Schistosoma mansoni infection.Clinical microbiology reviews · 1989Review
- Ultrastructure of the attack of eosinophils stimulated by blood mononuclear cell products on schistosomula of Schistosoma mansoni.The American journal of pathology · 1985Article
- Histopathological study of the attrition of challenge cercariae of Schistosoma mansoni in the skin of mice immunized by chronic infection and by use of highly X-irradiated cercariae.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1983Article
- Quantification, dynamics, and mechanisms of pulmonary inflammatory response around schistosomula of Schistosoma mansoni.The American journal of pathology · 1981Article
- Eosinophils versus neutrophils in host defense. Killing of newborn larvae of Trichinella spiralis by human granulocytes in vitro.The Journal of clinical investigation · 1979Article
- Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni.The Journal of experimental medicine · 1978Article
- A lung model of schistosome immunity in mice.The American journal of pathology · 1977Article
- Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils.The Journal of experimental medicine · 1977Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure of the mouse skin to Schistosoma mansoni cercariae gives rise to acute, exudative inflammation in both normal and immune mice, but the immune response is anamnestically accelerated and is oesinophil-enriched, thereby enhancing opportunities for tegumental contact of schistosomula with host leukocytes, particularly with eosinophils. Many of the inflammatory changes occurring within the first 48 hours after exposure are due to cercarial products, e.g., "penetration tracts," but some remain demonstrable when schistosomula metamorphosed in vitro are injected intradermally and are therefore directed against the schistosomula themselves, such as the leukocyte "streaming patterns" seen in their pathways. In contrast to earlier observations in primates, cellular responses to schistosomula in the mouse lung 4 days after penetration are minimal in either normal or immune mice. Thus, immune cellular responses to schistosomula in mice are limited to an early time period after cercarial penetration and are morphologically suggestive of an antibody-mediated response rather than of delayed hypersensitivity. Our observations complement earlier evidence suggesting that antibody-mediated host leukocyte contact with schistosomula initiates the killing of challenge parasites in immune mice, with the eosinophil probably playing a crucial role.
Indexed as
Identifiers
961823PMC2032531W1536116869What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.