ReviewPlant molecular biology1998
A model for RNA-mediated gene silencing in higher plants.
Review in Plant molecular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 213 citations in OpenAlex.
- Ecotype-specific sensitivity to DNA methylation inhibitors in Arabidopsis cmt3 mutants.Molecular genetics and genomics : MGG · 2026Article
- The role of microRNAs in neurodegenerative diseases: a review.Cell biology and toxicology · 2023Review
- Molecular Mechanisms of Phenylpropane-Synthesis-Related Genes Regulating the Shoot Blight Resistance ofInternational journal of molecular sciences · 2022Article
- Epigenetic Modifications: An Unexplored Facet of Exogenous RNA Application in Plants.Plants (Basel, Switzerland) · 2020Article
- RNAi-Based Biocontrol of Wheat Nematodes Using Natural Poly-Component Biostimulants.Frontiers in plant science · 2019Article
- Co-expression of Multiple Chimeric Fluorescent Fusion Proteins in an Efficient Way in Plants.Journal of visualized experiments : JoVE · 2018Article
- Improvement of the transient expression system for production of recombinant proteins in plants.Scientific reports · 2018Article
- Once for All: A Novel Robust System for Co-expression of Multiple Chimeric Fluorescent Fusion Proteins in Plants.Frontiers in plant science · 2017Article
- WOMEN IN CANCER PROFILE: Dude, where's my band?Endocrine-related cancer · 2016Article
- Article
- Gene technology for papaya ringspot virus disease management.TheScientificWorldJournal · 2014Review
- Field testing, gene flow assessment and pre-commercial studies on transgenic Solanum tuberosum spp. tuberosum (cv. Spunta) selected for PVY resistance in Argentina.Transgenic research · 2012Article
- Low relative humidity triggers RNA-directed de novo DNA methylation and suppression of genes controlling stomatal development.Journal of experimental botany · 2012Article
- Site-specific methylation in gene coding region underlies transcriptional silencing of the Phytochrome A epiallele in Arabidopsis thaliana.Plant molecular biology · 2012Article
- Transient co-expression of post-transcriptional gene silencing suppressors for increased in planta expression of a recombinant anthrax receptor fusion protein.International journal of molecular sciences · 2011Article
- The diverse roles of RNA helicases in RNAi.Cell cycle (Georgetown, Tex.) · 2009Article
- The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A.Nucleic acids research · 2008Article
- RNA interference: biology, mechanism, and applications.Microbiology and molecular biology reviews : MMBR · 2003Review
- Methylation of the exon/intron region in the Ubi1 promoter complex correlates with transgene silencing in barley.Plant molecular biology · 2003Article
- Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing.Journal of virology · 2003Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homology-dependent gene silencing (HdGS) which is the generic term for transcriptional gene silencing (TGS), post-transcriptional gene silencing (PTGS) and RNA-mediated virus-resistance (RmVR) has been shown to frequently occur in transgenic plants. The role of RNA as a target and initiator of PTGS and RmVR is more and more manifested. Because TGS is assumed to be induced by a DNA-DNA interaction-mediated promoter methylation, a possible involvement of RNA in TGS was not really considered up to now. In this review we attempt to demonstrate that all three types of HdGS could be triggered by one RNA-based mechanism. A model proposing TGS as a consequence of RNA-directed DNA methylation (RdDM) and a refined mRNA threshold mechanism are presented. In contrast to the view that high amounts of mRNA are required we assume that the concentration of RNAs that can serve as efficient templates for a plant-encoded RNA-directed RNA polymerase (RdRP) plays a key role in HdGS and possibly also in natural gene regulation of non-transformed cells. According to this idea a particular information must be encoded to render mRNA turn-over products a suitable RdRP substrate. It will be discussed that such a mechanism could account for the silencing phenomena of poorly transcribed transgenes. Finally, an explanation for the coherency between PTGS and DNA methylation is documented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.