ArticleOccupational and environmental medicine1998
Influence of biological and analytical variation on urine measurements for monitoring exposure to cadmium.
Article in Occupational and environmental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Method validation for (ultra)-trace element concentrations in urine for small sample volumes in large epidemiological studies: application to the population-based epidemiological multi-ethnic study of atherosclerosis (MESA).Analytical methods : advancing methods and applications · 2024Article
- Temporal variability of urinary cadmium in spot urine samples and first morning voids.Journal of exposure science & environmental epidemiology · 2017Article
- Cadmium exposure and endometrial cancer risk: A large midwestern U.S. population-based case-control study.PloS one · 2017Article
- Cadmium status among pediatric cancer patients in Egypt.Medicine · 2015Article
- Article
- Determinants and within-person variability of urinary cadmium concentrations among women in northern California.Environmental health perspectives · 2013Article
- Sources of cadmium exposure among healthy premenopausal women.The Science of the total environment · 2011Article
- Urinary cadmium, osteopenia, and osteoporosis in the US population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder.Respiratory research · 2010Article
- Urinary lead exposure and breast cancer risk in a population-based case-control study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
- Biological variations in cadmium, alpha 1-microglobulin, beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase in adult women in a non-polluted area.International archives of occupational and environmental health · 2008Article
- Decreases in urine specific gravity and urinary creatinine in elderly women.International archives of occupational and environmental health · 2005Article
- Effects of aging on cadmium and tubular dysfunction markers in urine from adult women in non-polluted areas.International archives of occupational and environmental health · 2005Article
- Article
- Land contamination and urinary abnormalities: cause for concern?Occupational and environmental medicine · 2003Article
- Variability of urinary cadmium excretion in spot urine samples, first morning voids, and 24 h urine in a healthy non-smoking population: implications for study design.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo define the mean intraindividual biological variation in urinary concentrations of cadmium and retinol binding protein (RBP) in untimed, random urine samples and the influence of creatinine or specific gravity correction on reducing this variation. The relation between biological variation and analytical variation in defining uncertainty in a single measurement and significant differences between successive measurements was explored.
methodsRepeat measurement study in subjects with either high historical exposure to cadmium but without current exposure, or unexposed volunteers. Standard statistical tools used in clinical laboratory medicine were applied to define intraindividual biological and analytical variation. RESULTS AND
conclusionBoth creatinine and specific gravity correction of urinary cadmium measurements in random urine samples seem to reduce the intraindividual variability compared with uncorrected values. With a standard definition, acceptable long term analytical precision for measurements of cadmium and RBP combined with creatinine analyses should be < 9% and < 15% respectively. The mean intraindividual biological variation of cadmium and RBP, expressed as creatinine corrected, was 18% and 40% respectively in the subjects exposed to cadmium. With the analytical precision used, significant differences (p < 0.05) between consecutive measurements for creatinine corrected urinary cadmium and RBP would need to show changes of > 54% and > 110% respectively. The relation between significant differences in consecutive results and differences in the analytical precision of the method used to measure the samples is described.
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