ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Substance P modulates NMDA responses and causes long-term protein synthesis-dependent modulation of the lamprey locomotor network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 74 citations in OpenAlex.
- Opiorphin and neuropathic pain: a promising treatment approach?Inflammopharmacology · 2025Review
- Respiratory frequency plasticity during development.Respiratory physiology & neurobiology · 2019Review
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- The Lesioned Spinal Cord Is a "New" Spinal Cord: Evidence from Functional Changes after Spinal Injury in Lamprey.Frontiers in neural circuits · 2017Review
- Short-Term Synaptic Plasticity at Interneuronal Synapses Could Sculpt Rhythmic Motor Patterns.Frontiers in neural circuits · 2016Article
- Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.Neural plasticity · 2015Article
- Biomarkers of cognitive dysfunction in traumatic brain injury.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Dynamic systems approaches and levels of analysis in the nervous system.Frontiers in physiology · 2013Article
- Manipulations of spinal cord excitability evoke developmentally-dependent compensatory changes in the lamprey spinal cord.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Complexities and uncertainties of neuronal network function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Metaplastic facilitation and ultrastructural changes in synaptic properties are associated with long-term modulation of the lamprey locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Gating and braking of short- and long-term modulatory effects by interactions between colocalized neuromodulators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord.The Journal of physiology · 2001Review
- Activity and calcium-dependent mechanisms maintain reliable interneuron synaptic transmission in a rhythmic neural network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Activity-dependent metaplasticity of inhibitory and excitatory synaptic transmission in the lamprey spinal cord locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Cellular and synaptic modulation underlying substance P-mediated plasticity of the lamprey locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: consequences for network pattern generation.Journal of computational neuroscienceArticle
- Spinal-Cord plasticity: independent and interactive effects of neuromodulator and activity-dependent plasticity.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tachykinin immunoreactivity is found in a ventromedial spinal plexus in the lamprey. Neurons in this plexus project bilaterally and are thus in a position to modulate locomotor networks on both sides of the spinal cord. We have examined the effects of the tachykinin substance P on NMDA-evoked locomotor activity. Brief (10 min) application of tachykinin neuropeptides results in a prolonged concentration-dependent (>24 hr) modulation of locomotor activity, shown by the increased burst frequency and more regular burst activity. These effects are blocked by the tachykinin antagonist spantide II. There are at least two phases to the burst frequency modulation. An initial phase (approximately 2 hr) is associated with the protein kinase C-dependent potentiation of cellular responses to NMDA. The long-lasting phase (>2 hr) appears to be protein synthesis-dependent, with protein synthesis inhibitors causing the increased burst frequency to recover after washing for 2-3 hr. The modulation of the burst regularity is caused by a separate effect of tachykinins, because unlike the burst frequency modulation it does not require the modulation of NMDA receptors for its induction and is blocked by H8, an inhibitor of cAMP- and cGMP-dependent protein kinases. The effects of substance P were mimicked by the dopamine D2 receptor antagonist eticlopride. The effects of eticlopride were blocked by the tachykinin antagonist spantide II, suggesting that eticlopride may endogenously release tachykinins. Because locomotor activity in vitro corresponds to that during swimming in intact animals, we suggest that endogenously released tachykinins will result in prolonged modulation of locomotor behavior.
Indexed as
Identifiers
9614253PMC6792700W1520703274What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.