ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Myosin Ibeta is located at tip link anchors in vestibular hair bundles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- The role of motor proteins in photoreceptor protein transport and visual function.Ophthalmic genetics · 2022Article
- Decades-old model of slow adaptation in sensory hair cells is not supported in mammals.Science advances · 2020Article
- A cryo-tomography-based volumetric model of the actin core of mouse vestibular hair cell stereocilia lacking plastin 1.Journal of structural biology · 2020Article
- Myosin 7 and its adaptors link cadherins to actin.Nature communications · 2017Article
- Chemomechanical regulation of myosin Ic cross-bridges: Deducing the elastic properties of an ensemble from single-molecule mechanisms.PLoS computational biology · 2017Article
- The elusive mechanotransduction machinery of hair cells.Current opinion in neurobiology · 2015Review
- Sensing sound: molecules that orchestrate mechanotransduction by hair cells.Trends in neurosciences · 2012Review
- The myosin superfamily at a glance.Journal of cell science · 2012Review
- Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin.Cellular and molecular life sciences : CMLS · 2011Article
- Review series: The cell biology of hearing.The Journal of cell biology · 2010Review
- Review
- Cadherins and mechanotransduction by hair cells.Current opinion in cell biology · 2008Review
- Review
- Stepwise morphological and functional maturation of mechanotransduction in rat outer hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Closure of supporting cell scar formations requires dynamic actin mechanisms.Hearing research · 2007Article
- A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Uptake of gentamicin by bullfrog saccular hair cells in vitro.Journal of the Association for Research in Otolaryngology : JARO · 2003Article
- Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- A novel antigen sensitive to calcium chelation that is associated with the tip links and kinocilial links of sensory hair bundles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies have suggested that myosin Ibeta mediates the adaptation of mechanoelectrical transduction in vestibular hair cells. An important prediction of this hypothesis is that myosin Ibeta should be found in the side insertional plaque, an osmiophilic hair bundle structure that anchors tip links and is thought to house the adaptation motor. To determine whether myosin Ibeta was situated properly to perform adaptation, we used immunofluorescence and immunoelectron microscopy with the monoclonal antibody mT2 to examine the distribution of myosin Ibeta in hair bundles of the bullfrog utricle. Although utricular hair cells differ in their rates and extent of adaptation [Baird RA (1994) Comparative transduction mechanisms of hair cells in the bullfrog utriculus. II. Sensitivity and response dynamics to hair bundle displacement. J Neurophysiol 71:685-705.], myosin Ibeta was present in all hair bundles, regardless of adaptation kinetics. Confirming that, nevertheless, it was positioned properly to mediate adaptation, myosin Ibeta was found at significantly higher levels in the side insertional plaque. Myosin Ibeta was also present at elevated levels at the second tip link anchor of a hair bundle, the tip insertional plaque, found at the tip of a stereocilium. These data support myosin Ibeta as the adaptation motor and are consistent with the suggestion that the motor serves to restore tension applied to transduction channels to an optimal level, albeit with different kinetics in different cell types.
Indexed as
Identifiers
9614235PMC6792677W2159052354What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.