ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
A myosin III from Limulus eyes is a clock-regulated phosphoprotein.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Myosin light chains: Teaching old dogs new tricks.Bioarchitecture · 2014Review
- What the clock tells the eye: lessons from an ancient arthropod.Integrative and comparative biology · 2013Review
- Opsin1-2, G(q)α and arrestin levels at Limulus rhabdoms are controlled by diurnal light and a circadian clock.The Journal of experimental biology · 2013Article
- Mouse class III myosins: kinase activity and phosphorylation sites.Journal of neurochemistry · 2011Article
- Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.Experimental eye research · 2009Article
- Structure of cone photoreceptors.Progress in retinal and eye research · 2009Review
- Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylation.Biochemistry · 2007Article
- Mechanisms controlling the sensitivity of the Limulus lateral eye in natural lighting.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2003Article
- Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus.Molecular biology of the cell · 2003Article
- Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Regulation of nonmuscle myosins by heavy chain phosphorylation.Journal of muscle research and cell motility · 2001Review
- The use of competitive PCR mimic to evaluate a Limulus lambda phage genomic DNA library.Cellular and molecular neurobiology · 2000Article
- Identification and analysis of the myosin superfamily in Drosophila: a database approach.Journal of muscle research and cell motility · 2000Review
- Modulation of the light response by cAMP in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Unconventional myosins at the crossroad of signal transduction and cytoskeleton remodeling.Protoplasma · 1999Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The lateral eyes of the horseshoe crab Limulus polyphemus undergo dramatic daily changes in structure and function that lead to enhanced retinal sensitivity and responsiveness to light at night. These changes are controlled by a circadian neural input that alters photoreceptor and pigment cell shape, pigment migration, and phototransduction. Clock input to the eyes also regulates photomechanical movements within photoreceptors, including membrane shedding. The biochemical mechanisms underlying these diverse effects of the clock on the retina are unknown, but a major biochemical consequence of activating clock input to the eyes is a rise in the concentration of cAMP in photoreceptors and the phosphorylation of a 122 kDa visual system-specific protein. We have cloned and sequenced cDNA encoding the clock-regulated 122 kDa phosphoprotein and show here that it is a new member of the myosin III family. We report that Limulus myosin III is similar to other unconventional myosins in that it binds to calmodulin in the absence of Ca2+; it is novel in that it is phosphorylated within its myosin globular head, probably by cAMP-dependent protein kinase. The protein is present throughout the photoreceptor, including the region occupied by the photosensitive rhabdom. We propose that the phosphorylation of Limulus myosin III is involved in one or more of the structural and functional changes that occur in Limulus eyes in response to clock input.
Indexed as
Identifiers
9614231PMC6792693W2143707560What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.